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KIP1 Kip1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852216, updated on 18-Sep-2024

Summary

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Official Symbol
KIP1
Official Full Name
Kip1p
Primary source
SGD:S000000159
Locus tag
YBL063W
See related
AllianceGenome:SGD:S000000159; FungiDB:YBL063W; VEuPathDB:YBL063W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CIN9
Summary
Enables microtubule motor activity. Involved in 2-micrometer plasmid partitioning; initial mitotic spindle pole body separation; and microtubule depolymerization. Located in spindle microtubule. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Orthologous to human KIF11 (kinesin family member 11). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See KIP1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (101886..105221)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Sef1p Neighboring gene thioredoxin peroxidase PRX1 Neighboring gene Skt5p Neighboring gene Arf family guanine nucleotide exchange factor YEL1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinesin-5 Kip1 is a bi-directional motor that stabilizes microtubules and tracks their plus-ends in vivo. Fridman V, et al. J Cell Sci, 2013 Sep 15. PMID 23868978
  2. Degradation of the kinesin Kip1p at anaphase onset is mediated by the anaphase-promoting complex and Cdc20p. Gordon DM, et al. Proc Natl Acad Sci U S A, 2001 Oct 23. PMID 11606759, Free PMC Article
  3. The kinesin-related protein Kip1p of Saccharomyces cerevisiae is bipolar. Gordon DM, et al. J Biol Chem, 1999 Oct 1. PMID 10497250
  4. Intracellular functions and motile properties of bi-directional kinesin-5 Cin8 are regulated by neck linker docking. Goldstein-Levitin A, et al. Elife, 2021 Aug 13. PMID 34387192, Free PMC Article
  5. Directionality of individual kinesin-5 Cin8 motors is modulated by loop 8, ionic strength and microtubule geometry. Gerson-Gurwitz A, et al. EMBO J, 2011 Nov 18. PMID 22101328, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clb2/Cdc28 drives spindle pole separation by direct phosphorylation of Kip1 and Cin8.
    Title: B-cyclin/CDKs regulate mitotic spindle assembly by phosphorylating kinesins-5 in budding yeast.
  2. Results show that the 2 micron plasmid of Saccharomyces cerevisiae uses the Kip1 motor, but not the functionally redundant Cin8 motor, for its precise nuclear localization and equal segregation.
    Title: The selfish yeast plasmid uses the nuclear motor Kip1p but not Cin8p for its localization and equal segregation.
  3. Study finds in budding yeast that the widely conserved kinesin-5 sliding motor proteins, Cin8p and Kip1p, mediate chromosome congression by suppressing kMT plus-end assembly of longer kinetochore microtubules.
    Title: Chromosome congression by Kinesin-5 motor-mediated disassembly of longer kinetochore microtubules.
  4. spindle elongation in anaphase in Saccharomyces cerevisiae cells mutated for the kinesin-5 motor protein Kip1
    Title: Slk19-dependent mid-anaphase pause in kinesin-5-mutated cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in 2-micrometer plasmid partitioning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in initial mitotic spindle pole body separation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in initial mitotic spindle pole body separation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex TAS
Traceable Author Statement
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Kip1p
NP_009490.1
  • Kinesin-related motor protein; tracks plus-ends and stabilizes microtubules; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    101886..105221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178303.1 → NP_009490.1  TPA: Kip1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009490.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPT7, P28742
    UniProtKB/TrEMBL
    B3LNJ8, B5VDS4, C8Z3T3
    Conserved Domains (2) summary
    TIGR01612
    Location:423 → 948
    235kDa-fam; reticulocyte binding/rhoptry protein
    cd01364
    Location:50 → 419
    KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28742.1

Gene LinkOut

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