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APL3 Apl3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852243, updated on 17-May-2024

Summary

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Gene symbol
APL3
Gene description
Apl3p
Primary source
FungiDB:YBL037W
Locus tag
YBL037W
See related
SGD:S000000133; AllianceGenome:SGD:S000000133; VEuPathDB:YBL037W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable clathrin adaptor activity. Predicted to be involved in clathrin-dependent endocytosis. Located in cellular bud neck. Part of AP-2 adaptor complex. Orthologous to several human genes including AP2A2 (adaptor related protein complex 2 subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See APL3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (147209..150286)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene CTP synthase URA7 Neighboring gene mitochondrial 54S ribosomal protein YmL47 Neighboring gene uncharacterized protein Neighboring gene DNA-directed DNA polymerase alpha subunit POL12

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast endocytic adaptor AP-2 binds the stress sensor Mid2 and functions in polarized cell responses. Chapa-y-Lazo B, et al. Traffic, 2014 May. PMID 24460703, Free PMC Article
  2. Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex. Panek HR, et al. EMBO J, 1997 Jul 16. PMID 9250663, Free PMC Article
  3. Adaptor complex-independent clathrin function in yeast. Yeung BG, et al. Mol Biol Cell, 1999 Nov. PMID 10564262, Free PMC Article
  4. Alpha-arrestins Aly1/Art6 and Aly2/Art3 regulate trafficking of the glycerophosphoinositol transporter Git1 and impact phospholipid homeostasis. Robinson BP, et al. Biol Cell, 2022 Jan. PMID 34562280
  5. Resolving the composition of protein complexes using a MALDI LTQ Orbitrap. Luo Y, et al. J Am Soc Mass Spectrom, 2010 Jan. PMID 19822444, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IC
Inferred by Curator
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-2 adaptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of AP-2 adaptor complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Apl3p
NP_009516.1
  • Alpha-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    147209..150286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178277.1 → NP_009516.1  TPA: Apl3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009516.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPW2, P38065
    UniProtKB/TrEMBL
    A0A8H4F6G8, A6ZKR0, N1P8S3
    Conserved Domains (2) summary
    pfam02296
    Location:901 → 1018
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:38 → 649
    Adaptin_N; Adaptin N terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38065.1

Gene LinkOut

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