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SCO2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852312, updated on 11-Sep-2024

Summary

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Official Symbol
SCO2
Primary source
SGD:S000000228
Locus tag
YBR024W
See related
AllianceGenome:SGD:S000000228; FungiDB:YBR024W; VEuPathDB:YBR024W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables copper ion binding activity. Involved in cell redox homeostasis and cellular response to oxidative stress. Located in mitochondrial membrane. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease; fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 1; hypertrophic cardiomyopathy; and myopia. Orthologous to human SCO1 (synthesis of cytochrome C oxidase 1) and SCO2 (synthesis of cytochrome C oxidase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (289445..290350)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ADP-ribose 1''-phosphate phosphatase Neighboring gene chitin synthase CHS3 Neighboring gene Obg-like ATPase Neighboring gene enoyl-[acyl-carrier-protein] reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel insights into phenotype and mitochondrial proteome of yeast mutants lacking proteins Sco1p or Sco2p. Gamberi T, et al. Mitochondrion, 2009 Apr. PMID 19460303
  2. Mitochondrial copper metabolism in yeast: mutational analysis of Sco1p involved in the biogenesis of cytochrome c oxidase. Rentzsch A, et al. Curr Genet, 1999 Mar. PMID 10079328
  3. Phosphatidylserine synthesis is essential for viability of the human fungal pathogen Cryptococcus neoformans. Konarzewska P, et al. J Biol Chem, 2019 Feb 15. PMID 30602568, Free PMC Article
  4. Molecular characterization of Saccharomyces cerevisiae Sco2p reveals a high degree of redundancy with Sco1p. Lode A, et al. Yeast, 2002 Aug. PMID 12125048
  5. SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae. Glerum DM, et al. J Biol Chem, 1996 Aug 23. PMID 8702795

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we found that simultaneous deletion of Coa6 and Sco2 completely abrogates Cox2 biogenesis.
    Title: Mitochondrial disease genes COA6, COX6B and SCO2 have overlapping roles in COX2 biogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables copper chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables copper ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular copper ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in respiratory chain complex IV assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative thioredoxin peroxidase SCO2
NP_009580.1
  • Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    289445..290350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178372.1 → NP_009580.1  TPA: putative thioredoxin peroxidase SCO2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009580.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ26, P38072
    UniProtKB/TrEMBL
    A6ZKX0, B5VDZ4, C7GM28, C8Z418, G2W931
    Conserved Domains (1) summary
    COG1999
    Location:80 → 282
    Sco1; Cytochrome oxidase Cu insertion factor, SCO1/SenC/PrrC family [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38072.1

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