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SEC66 Sec63 complex subunit SEC66 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852469, updated on 4-Aug-2024

Summary

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Gene symbol
SEC66
Gene description
Sec63 complex subunit SEC66
Primary source
FungiDB:YBR171W
Locus tag
YBR171W
See related
SGD:S000000375; AllianceGenome:SGD:S000000375; VEuPathDB:YBR171W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HSS1; KAR7; SEC71
Summary
Contributes to protein transmembrane transporter activity. Involved in filamentous growth and posttranslational protein targeting to membrane, translocation. Located in endoplasmic reticulum membrane. Part of Sec62/Sec63 complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SEC66 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (578364..578984)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene adenyl-nucleotide exchange factor SSE2 Neighboring gene nuclear protein localization protein 4 Neighboring gene Smy2p Neighboring gene Ump1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional characterization of Sec66p, a new subunit of the polypeptide translocation apparatus in the yeast endoplasmic reticulum. Feldheim D, et al. Mol Biol Cell, 1993 Sep. PMID 8257795, Free PMC Article
  2. Nuclear inner membrane fusion facilitated by yeast Jem1p is required for spindle pole body fusion but not for the first mitotic nuclear division during yeast mating. Nishikawa S, et al. Genes Cells, 2008 Nov. PMID 19090812
  3. Rer1p, a retrieval receptor for ER membrane proteins, recognizes transmembrane domains in multiple modes. Sato K, et al. Mol Biol Cell, 2003 Sep. PMID 12972550, Free PMC Article
  4. New COP1-binding motifs involved in ER retrieval. Cosson P, et al. EMBO J, 1998 Dec 1. PMID 9843492, Free PMC Article
  5. Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus. Kurihara T, et al. Mol Biol Cell, 1993 Sep. PMID 8257794, Free PMC Article

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sec66-mediated regulation of Pom152 plays an nuclear pore complex-independent role in the control of spindle-pole body duplication
    Title: Sec66-Dependent Regulation of Yeast Spindle-Pole Body Duplication Through Pom152.
  2. Sec71p facilitates nuclear outer-membrane fusion.
    Title: Nuclear inner membrane fusion facilitated by yeast Jem1p is required for spindle pole body fusion but not for the first mitotic nuclear division during yeast mating.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to protein transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in filamentous growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-translational protein targeting to membrane, translocation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-translational protein targeting to membrane, translocation IEA
Inferred from Electronic Annotation
more info
  
involved_in post-translational protein targeting to membrane, translocation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in post-translational protein targeting to membrane, translocation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Sec62/Sec63 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Sec62/Sec63 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Sec62/Sec63 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cell periphery HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sec63 complex subunit SEC66
NP_009730.3
  • Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and translocation into the ER; other members are Sec63p, Sec62p, and Sec72p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    578364..578984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178519.3 → NP_009730.3  TPA: Sec63 complex subunit SEC66 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009730.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQG7, P33754
    UniProtKB/TrEMBL
    A6ZLB4, B3LMY8, C7GUI6, D3UER6, G2W9H4, N1P9J2
    Conserved Domains (1) summary
    pfam09802
    Location:27 → 197
    Sec66; Preprotein translocase subunit Sec66
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33754.1

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