ARC40 Arc40p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ARC40
Gene description: Arc40p
Primary source: FungiDB:YBR234C
Locus tag: YBR234C
See related: SGD:S000000438; AllianceGenome:SGD:S000000438; VEuPathDB:YBR234C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ubiquitin binding activity. Involved in actin cortical patch organization and positive regulation of Arp2/3 complex-mediated actin nucleation. Part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; myelodysplastic syndrome; and pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A) and ARPC1B (actin related protein 2/3 complex subunit 1B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ARC40 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (685438..686592, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p40/ARPC1 performs at least three distinct, essential functions in regulating Arp2/3 complex-mediated actin assembly
Title: The p40/ARPC1 subunit of Arp2/3 complex performs multiple essential roles in WASp-regulated actin nucleation.
study showed that subunit ARPC1/Arc40 of the yeast actin-related protein Arp2/3 complex is indeed a stable component of the complex and contains an important contact site for the VCA domain of Wiskott-Aldrich syndrome protein family activators
Title: ARPC1/Arc40 mediates the interaction of the actin-related protein 2 and 3 complex with Wiskott-Aldrich syndrome protein family activators.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in actin cortical patch organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of Arp2/3 protein complex	IEA Inferred from Electronic Annotation more info
located_in actin cortical patch	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Arc40p

NP_009793.1

Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

685438..686592 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178582.1 → NP_009793.1 TPA: Arc40p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009793.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQN0, P38328

UniProtKB/TrEMBL

A6ZLH3, B3LMS8, B5VEI3, C7GMR9, G2W9N7, N1P9L6

Conserved Domains (2) summary

COG2319
Location:5 → 315

WD40; WD40 repeat [General function prediction only]

sd00039
Location:22 → 61

7WD40; WD40 repeat [structural motif]