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SHM1 glycine hydroxymethyltransferase SHM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852565, updated on 18-Sep-2024

Summary

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Official Symbol
SHM1
Official Full Name
glycine hydroxymethyltransferase SHM1
Primary source
SGD:S000000467
Locus tag
YBR263W
See related
AllianceGenome:SGD:S000000467; FungiDB:YBR263W; VEuPathDB:YBR263W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SHMT1; TMP3
Summary
Enables glycine hydroxymethyltransferase activity. Involved in one-carbon metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human SHMT1 (serine hydroxymethyltransferase 1) and SHMT2 (serine hydroxymethyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SHM1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (736264..737736)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene N-terminal protein methyltransferase Neighboring gene Mic12p Neighboring gene Rab family GTPase YPT10 Neighboring gene 3-dehydrosphinganine reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of the genes encoding the serine hydroxymethyltransferases from Saccharomyces cerevisiae. Taylor BV, et al. Adv Exp Med Biol, 1993. PMID 8304212
  2. Isolation and properties of a thymidylate-less mutant in Saccharomyces cerevisiae. Luzzati M. Eur J Biochem, 1975 Aug 15. PMID 1100397
  3. Mitochondrial and cytoplasmic distribution in Saccharmoyces cerevisiae of enzymes involved in folate-coenzyme-mediated one-carbon-group transfer. A genetic and biochemical study of the enzyme deficiencies in mutants tmp3 and ade3. Zelikson R, et al. Eur J Biochem, 1977 Sep 15. PMID 334546
  4. Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae. Kastanos EK, et al. Biochemistry, 1997 Dec 2. PMID 9398220
  5. Two forms of serine transhydroxymethylase, one absent in a thymidylate-less mutant in Saccharomyces cerevisiae. Zelikson R, et al. Eur J Biochem, 1976 Apr 15. PMID 6271

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycine hydroxymethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine hydroxymethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycine hydroxymethyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycine biosynthetic process from serine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
  
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in one-carbon metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in one-carbon metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrahydrofolate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
glycine hydroxymethyltransferase SHM1
NP_009822.4
  • Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    736264..737736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178611.3 → NP_009822.4  TPA: glycine hydroxymethyltransferase SHM1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009822.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQR0, P37292
    UniProtKB/TrEMBL
    A6ZLK3, B3LMP8, C7GMW7, D3UF11, G2W9R8, N1P767
    Conserved Domains (1) summary
    pfam00464
    Location:33 → 432
    SHMT; Serine hydroxymethyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37292.2

Gene LinkOut

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