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EFM2 S-adenosylmethionine-dependent methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852574, updated on 1-Aug-2024

Summary

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Gene symbol
EFM2
Gene description
S-adenosylmethionine-dependent methyltransferase
Primary source
FungiDB:YBR271W
Locus tag
YBR271W
See related
SGD:S000000475; AllianceGenome:SGD:S000000475; VEuPathDB:YBR271W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine dimethylation and positive regulation of translational termination. Located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human METTL23 (methyltransferase like 23). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See EFM2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (744852..746111)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Sdh8p Neighboring gene Bit2p Neighboring gene Hsm3p Neighboring gene Ubx7p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Elongation factor methyltransferase 3--a novel eukaryotic lysine methyltransferase. Zhang L, et al. Biochem Biophys Res Commun, 2014 Aug 22. PMID 25086354
  2. Translational roles of elongation factor 2 protein lysine methylation. Dzialo MC, et al. J Biol Chem, 2014 Oct 31. PMID 25231983, Free PMC Article
  3. Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases. Couttas TA, et al. Proteomics, 2012 Apr. PMID 22522802
  4. Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome. Wlodarski T, et al. PLoS One, 2011. PMID 21858014, Free PMC Article
  5. Stoichiometry of Saccharomyces cerevisiae lysine methylation: insights into non-histone protein lysine methyltransferase activity. Hart-Smith G, et al. J Proteome Res, 2014 Mar 7. PMID 24517342

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-lysine N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translational termination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
S-adenosylmethionine-dependent methyltransferase
NP_009830.3
  • S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which dimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 613 and methylates EF3 (Yef3p) at lysine 187; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; involved in regulation of translational termination; predicted involvement in ribosome biogenesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    744852..746111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178619.3 → NP_009830.3  TPA: S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009830.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQR7, P38347
    UniProtKB/TrEMBL
    A6ZLL0, B3LMP1, B5VEL6, C7GMW0, D3UF19, G2W9S5, N1P8V0
    Conserved Domains (1) summary
    cl17173
    Location:213 → 344
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38347.1

Gene LinkOut

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