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PPS1 tyrosine/serine/threonine protein phosphatase PPS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852579, updated on 4-Aug-2024

Summary

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Gene symbol
PPS1
Gene description
tyrosine/serine/threonine protein phosphatase PPS1
Primary source
FungiDB:YBR276C
Locus tag
YBR276C
See related
SGD:S000000480; AllianceGenome:SGD:S000000480; VEuPathDB:YBR276C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein tyrosine/serine/threonine phosphatase activity. Involved in nuclear DNA replication and protein dephosphorylation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PPS1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (757620..760043, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase CHK1 Neighboring gene DNA-binding protein RIF1 Neighboring gene DNA polymerase epsilon noncatalytic subunit Neighboring gene Paf1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The PPS1 gene of Saccharomyces cerevisiae codes for a dual specificity protein phosphatase with a role in the DNA synthesis phase of the cell cycle. Ernsting BR, et al. J Biol Chem, 1997 Apr 4. PMID 9083070
  2. Overexpressed ribosomal proteins suppress defective chaperonins in Saccharomyces cerevisiae. Kabir MA, et al. FEMS Yeast Res, 2008 Dec. PMID 18680526
  3. A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast. Gazy I, et al. G3 (Bethesda), 2013 May 20. PMID 23704284, Free PMC Article
  4. Rewiring of genetic networks in response to DNA damage. Bandyopadhyay S, et al. Science, 2010 Dec 3. PMID 21127252, Free PMC Article
  5. Complete DNA sequence of yeast chromosome II. Feldmann H, et al. EMBO J, 1994 Dec 15. PMID 7813418, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nuclear DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tyrosine/serine/threonine protein phosphatase PPS1
NP_009835.3
  • Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    757620..760043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178624.3 → NP_009835.3  TPA: tyrosine/serine/threonine protein phosphatase PPS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009835.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQS2, P38148
    UniProtKB/TrEMBL
    A6ZLL5, B5VEM2, N1P9N4
    Conserved Domains (1) summary
    cd14516
    Location:580 → 779
    DSP_fungal_PPS1; dual specificity phosphatase domain of fungal dual specificity protein phosphatase PPS1-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38148.1

Gene LinkOut

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