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TOS8 Tos8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852783, updated on 1-Aug-2024

Summary

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Gene symbol
TOS8
Gene description
Tos8p
Primary source
FungiDB:YGL096W
Locus tag
YGL096W
See related
SGD:S000003064; AllianceGenome:SGD:S000003064; VEuPathDB:YGL096W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables chromatin binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in chromatin. Human ortholog(s) of this gene implicated in cleft palate, cardiac defects, and intellectual disabillity. Orthologous to several human genes including PKNOX1 (PBX/knotted 1 homeobox 1) and PKNOX2 (PBX/knotted 1 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TOS8 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (325331..326161)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-His Neighboring gene Ran guanyl-nucleotide exchange factor Neighboring gene tRNA-Glu Neighboring gene Vps45p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional Profiling of Biofilm Regulators Identified by an Overexpression Screen in Saccharomyces cerevisiae. Cromie GA, et al. G3 (Bethesda), 2017 Aug 7. PMID 28673928, Free PMC Article
  2. Disruption and phenotypic analysis of six open reading frames from the left arm of Saccharomyces cerevisiae chromosome VII. Lillo JA, et al. Yeast, 2000 Mar 15. PMID 10669874
  3. Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Horak CE, et al. Genes Dev, 2002 Dec 1. PMID 12464632, Free PMC Article
  4. Dynamics of Cdk1 substrate specificity during the cell cycle. Kõivomägi M, et al. Mol Cell, 2011 Jun 10. PMID 21658602, Free PMC Article
  5. Functional Analysis of Kinases and Transcription Factors in Saccharomyces cerevisiae Using an Integrated Overexpression Library. Youn JY, et al. G3 (Bethesda), 2017 Mar 10. PMID 28122947, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tos8p
NP_011419.1
  • Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    325331..326161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180961.1 → NP_011419.1  TPA: Tos8p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011419.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU49, P53147
    UniProtKB/TrEMBL
    A6ZU84, B3LHG1, C8Z8F2, N1P9P8
    Conserved Domains (1) summary
    pfam05920
    Location:212 → 251
    Homeobox_KN; Homeobox KN domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53147.1

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