TDH3 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TDH3
Official Full Name: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3
Primary source: SGD:S000003424
Locus tag: YGR192C
See related: AllianceGenome:SGD:S000003424; FungiDB:YGR192C; VEuPathDB:YGR192C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GLD1; HSP35; HSP36; SSS2
Summary: Enables several functions, including glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; heme binding activity; and melatonin binding activity. Involved in several processes, including gluconeogenesis; glycolytic process; and heme transport. Located in several cellular components, including fungal-type cell wall; lipid droplet; and mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including GAPDH (glyceraldehyde-3-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TDH3 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (882812..883810, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Active compensation for changes in TDH3 expression mediated by direct regulators of TDH3 in Saccharomyces cerevisiae.
Title: Active compensation for changes in TDH3 expression mediated by direct regulators of TDH3 in Saccharomyces cerevisiae.
Aberrant Intracellular pH Regulation Limiting Glyceraldehyde-3-Phosphate Dehydrogenase Activity in the Glucose-Sensitive Yeast tps1Delta Mutant.
Title: Aberrant Intracellular pH Regulation Limiting Glyceraldehyde-3-Phosphate Dehydrogenase Activity in the Glucose-Sensitive Yeast tps1Δ Mutant.
The formation of hybrid complexes between isoenzymes of glyceraldehyde-3-phosphate dehydrogenase regulates its aggregation state, the glycolytic activity and sphingolipid status in Saccharomyces cerevisiae.
Title: The formation of hybrid complexes between isoenzymes of glyceraldehyde-3-phosphate dehydrogenase regulates its aggregation state, the glycolytic activity and sphingolipid status in Saccharomyces cerevisiae.
Here, we quantify the fitness effects of altering expression noise for the TDH3 gene in Saccharomyces cerevisiae. We show that increases in expression noise can be deleterious or beneficial depending on the difference between the average expression level of a genotype and the expression level maximizing fitness.
Title: Fitness effects of altering gene expression noise in Saccharomyces cerevisiae.
we find that cis- and trans-regulatory mutations differ significantly in their effects on both TDH3 average expression level and expression noise, with cis-regulatory mutations skewed toward decreased expression and increased expression noise, while trans-regulatory mutations are skewed toward increased expression and decreased expression noise.
Title: Contrasting Frequencies and Effects of cis- and trans-Regulatory Mutations Affecting Gene Expression.
genetic assay suggests that Tdh3, an NAD(+)-binding protein, influences nuclear NAD(+) levels; we speculate that Tdh3 links nuclear Sir2 with NAD(+) from the cytoplasm.
Title: Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase) is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination.
crystals of glyceraldehyde-3-phosphate dehydrogenase 3 belonged to space group I4(1)22, with unit-cell parameters a = b = 116.13, c = 119.21 A
Title: Preliminary crystallographic analysis of glyceraldehyde-3-phosphate dehydrogenase 3 from Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IDA Inferred from Direct Assay more info	PubMed
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables melatonin binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in heme transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in external encapsulating structure	IEA Inferred from Electronic Annotation more info
located_in fungal-type cell wall	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3

NP_011708.3

EC 1.2.1.12

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bacteria; moonlighting role as an AU-rich mRNA binding protein that binds to the FAS1 mRNA and controls periodic abundance of Fas1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

882812..883810 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181321.3 → NP_011708.3 TPA: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011708.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUX4, P00359, Q6Q5P9

UniProtKB/TrEMBL

A6ZUK2, B3LI45, B5VJD4, C8Z985, G2WES0, N1P2H7

Conserved Domains (1) summary

PLN02272
Location:2 → 330

PLN02272; glyceraldehyde-3-phosphate dehydrogenase