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CAB4 putative pantetheine-phosphate adenylyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853194, updated on 1-Aug-2024

Summary

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Gene symbol
CAB4
Gene description
putative pantetheine-phosphate adenylyltransferase
Primary source
FungiDB:YGR277C
Locus tag
YGR277C
See related
SGD:S000003509; AllianceGenome:SGD:S000003509; VEuPathDB:YGR277C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Involved in coenzyme A biosynthetic process. Located in cytoplasm and nucleus. Part of CoA-synthesizing protein complex. Used to study cancer. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia. Orthologous to human COASY (Coenzyme A synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CAB4 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1045644..1046561, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Rtt102p Neighboring gene Rnh70p Neighboring gene U2-type spliceosomal complex subunit CWC22 Neighboring gene putative family 17 glucosidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. Olzhausen J, et al. FEMS Yeast Res, 2013 Sep. PMID 23789928
  2. Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Olzhausen J, et al. Curr Genet, 2009 Apr. PMID 19266201
  3. Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway. Olzhausen J, et al. Appl Microbiol Biotechnol, 2021 Oct. PMID 34491400, Free PMC Article
  4. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. Daugherty M, et al. J Biol Chem, 2002 Jun 14. PMID 11923312
  5. Cell Lysate Microarray for Mapping the Network of Genetic Regulators for Histone Marks. Cheng L, et al. Mol Cell Proteomics, 2018 Sep. PMID 29871872, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables dephospho-CoA kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pantetheine-phosphate adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pantetheine-phosphate adenylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in coenzyme A biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in coenzyme A biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of CoA-synthesizing protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative pantetheine-phosphate adenylyltransferase
NP_011793.3
  • Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; involved in histone acylation; probable pantetheine-phosphate adenylyltransferase (PPAT); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT) and by human COASY

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1045644..1046561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181406.3 → NP_011793.3  TPA: putative pantetheine-phosphate adenylyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011793.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV54, P53332
    UniProtKB/TrEMBL
    A6ZUT3, B3LHW7, C7GNF8, G2WF00, N1P9Z7
    Conserved Domains (1) summary
    cd02164
    Location:144 → 288
    PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53332.1

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