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UPA1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853200, updated on 11-Sep-2024

Summary

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Official Symbol
UPA1
Primary source
SGD:S000003515
Locus tag
YGR283C
See related
AllianceGenome:SGD:S000003515; FungiDB:YGR283C; VEuPathDB:YGR283C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Located in nucleolus. Orthologous to human SPOUT1 (SPOUT domain containing methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1059015..1060040, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette transporter YOR1 Neighboring gene glucan 1,3-beta-glucosidase Neighboring gene Erv29p Neighboring gene zuotin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae. Anderson JB, et al. Genetics, 2003 Apr. PMID 12702675, Free PMC Article
  2. Probabilistic approach to predicting substrate specificity of methyltransferases. Szczepińska T, et al. PLoS Comput Biol, 2014 Mar. PMID 24651469, Free PMC Article
  3. Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome. Wlodarski T, et al. PLoS One, 2011. PMID 21858014, Free PMC Article
  4. Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation. Young BD, et al. Biochemistry, 2012 Jun 26. PMID 22650761, Free PMC Article
  5. The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes. Wade CH, et al. Yeast, 2006 Mar. PMID 16544271

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in methylation IC
Inferred by Curator
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative methyltransferase
NP_011799.3
  • Putative methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus; YGR283C has a paralog, YMR310C, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1059015..1060040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181412.3 → NP_011799.3  TPA: putative methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011799.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV60, P53336
    UniProtKB/TrEMBL
    A6ZUT9, G2WF06
    Conserved Domains (1) summary
    COG2106
    Location:35 → 339
    MTH1; Predicted RNA methylase MTH1, SPOUT superfamily [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53336.1

Gene LinkOut

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