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TOK1 Tok1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853352, updated on 18-Sep-2024

Summary

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Official Symbol
TOK1
Official Full Name
Tok1p
Primary source
SGD:S000003629
Locus tag
YJL093C
See related
AllianceGenome:SGD:S000003629; FungiDB:YJL093C; VEuPathDB:YJL093C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DUK1; YKC1; YPK1
Summary
Enables voltage-gated potassium channel activity. Involved in cellular potassium ion homeostasis. Located in plasma membrane. Human ortholog(s) of this gene implicated in Birk-Barel syndrome; migraine with aura; and primary pulmonary hypertension. Orthologous to several human genes including KCNK10 (potassium two pore domain channel subfamily K member 10); KCNK16 (potassium two pore domain channel subfamily K member 16); and KCNK2 (potassium two pore domain channel subfamily K member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TOK1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (254737..256812, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase BCK1 Neighboring gene Kha1p Neighboring gene DNA helicase SRS2 Neighboring gene glucosaminyl-phosphotidylinositol O-acyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional consequences of leucine and tyrosine mutations in the dual pore motifs of the yeast K(+) channel, Tok1p. Roller A, et al. Pflugers Arch, 2008 Aug. PMID 18421473
  2. Interactive domains between pore loops of the yeast K+ channel TOK1 associate with extracellular K+ sensitivity. Johansson I, et al. Biochem J, 2006 Feb 1. PMID 16287426, Free PMC Article
  3. In the yeast potassium channel, Tok1p, the external ring of aspartate residues modulates both gating and conductance. Roller A, et al. Pflugers Arch, 2005 Nov. PMID 16133265
  4. The carboxyl tail forms a discrete functional domain that blocks closure of the yeast K+ channel. Loukin SH, et al. Proc Natl Acad Sci U S A, 2002 Feb 19. PMID 11854493, Free PMC Article
  5. Carboxyl tail prevents yeast K(+) channel closure: proposal of an integrated model of TOK1 gating. Loukin SH, et al. Biophys J, 2002 Feb. PMID 11806920, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results describe the functional consequences of the structural asymmetry associated with leucine and tyrosine mutations in the dual pore motifs of the yeast potassium channel, Tok1p.
    Title: Functional consequences of leucine and tyrosine mutations in the dual pore motifs of the yeast K(+) channel, Tok1p.
  2. results demarcate extracellular domains that are associated with the K+-sensitivity of TOK1
    Title: Interactive domains between pore loops of the yeast K+ channel TOK1 associate with extracellular K+ sensitivity.
  3. Two negative residues in TOK1, Asp292 and Asp426, near the mouth of the assembled channel, modulate both kinetics and conductance of the channel.
    Title: In the yeast potassium channel, Tok1p, the external ring of aspartate residues modulates both gating and conductance.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular potassium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular potassium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Tok1p
NP_012442.1
  • Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    254737..256812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181526.1 → NP_012442.1  TPA: Tok1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012442.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW91, P40310, Q05721
    UniProtKB/TrEMBL
    A6ZPN2, B3LQ20, B5VL82, C7GR21, C8ZBC0, G2WGS5, N1NZT0
    Conserved Domains (1) summary
    pfam07885
    Location:388 → 462
    Ion_trans_2; Ion channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40310.1

Gene LinkOut

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