U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TIM54 Tim54p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853392, updated on 1-Aug-2024

Summary

Go to the top of the page Help
Gene symbol
TIM54
Gene description
Tim54p
Primary source
FungiDB:YJL054W
Locus tag
YJL054W
See related
SGD:S000003590; AllianceGenome:SGD:S000003590; VEuPathDB:YJL054W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to protein transmembrane transporter activity. Involved in protein insertion into mitochondrial inner membrane. Located in mitochondrion. Part of TIM22 mitochondrial import inner membrane insertion complex. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TIM54 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (334265..335701)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Zap1p Neighboring gene Log1p Neighboring gene retromer subunit PEP8 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Conserved regions of budding yeast Tim22 have a role in structural organization of the carrier translocase. Kumar A, et al. J Cell Sci, 2020 Jul 29. PMID 32591483
  2. Phosphatidylcholine Affects Inner Membrane Protein Translocases of Mitochondria. Schuler MH, et al. J Biol Chem, 2016 Sep 2. PMID 27402832, Free PMC Article
  3. The assembly pathway of the mitochondrial carrier translocase involves four preprotein translocases. Wagner K, et al. Mol Cell Biol, 2008 Jul. PMID 18458057, Free PMC Article
  4. The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane. Kerscher O, et al. J Cell Biol, 1997 Dec 29. PMID 9412462, Free PMC Article
  5. Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex. Endres M, et al. EMBO J, 1999 Jun 15. PMID 10369662, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tim54p links protein import, assembly, and turnover pathways in the mitochondrion.
    Title: Tim54p connects inner membrane assembly and proteolytic pathways in the mitochondrion.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
NOT enables lipid kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to protein transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein insertion into mitochondrial inner membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in sphingolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Tim54p
NP_012481.3
  • Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    334265..335701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181487.3 → NP_012481.3  TPA: Tim54p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012481.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWC8, P47045
    UniProtKB/TrEMBL
    B3LQ56, G2WGW2, N1P358
    Conserved Domains (1) summary
    pfam11711
    Location:20 → 466
    Tim54; Inner membrane protein import complex subunit Tim54
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47045.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous