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STRIP1 striatin interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 85369, updated on 10-Dec-2024

Summary

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Official Symbol
STRIP1provided by HGNC
Official Full Name
striatin interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:25916
See related
Ensembl:ENSG00000143093 MIM:617918; AllianceGenome:HGNC:25916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM40A; FAR11A
Summary
This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in testis (RPKM 12.7), bone marrow (RPKM 10.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See STRIP1 in Genome Data Viewer
Location:
1p13.3
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (110031577..110054641)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (110041710..110064768)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110574199..110597263)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110453680-110454180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110454181-110454681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110473698-110474646 Neighboring gene colony stimulating factor 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110502441-110503012 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110503013-110503582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1164 Neighboring gene adenosylhomocysteinase like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1458 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:110560640-110561839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1459 Neighboring gene uncharacterized LOC105378895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1166 Neighboring gene ALX homeobox 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1167 Neighboring gene long intergenic non-protein coding RNA 1397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1461

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization. Kean MJ, et al. J Biol Chem, 2011 Jul 15. PMID 21561862, Free PMC Article
  2. The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs. Suryavanshi N, et al. BMC Cell Biol, 2018 Dec 3. PMID 30509168, Free PMC Article
  3. Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Tang Y, et al. Cell Discov, 2019. PMID 30622739, Free PMC Article
  4. Cryo-EM structure of the Hippo signaling integrator human STRIPAK. Jeong BC, et al. Nat Struct Mol Biol, 2021 Mar. PMID 33633399, Free PMC Article
  5. Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. Kemp HA, et al. Mol Cell Biol, 2003 Mar. PMID 12588993, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results demonstrate the importance of the FAM40 proteins for endothelial cell physiology, and suggest that they act as part of the CCM3-containing STRIPAK complex.
    Title: The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs.
  2. STRIP1 is required for mesenchymal cell migration and is enriched in cellular protrusions in mesenchymal migrating cells.
    Title: STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo.
  3. this study propose that the STRIPAK complex, FAM40A, FAM40B and STRN3, regulates the mode of cancer cell migration by controlling the activity of MST3 and 4, which locally coordinate the phosphorylation of ERM proteins and inhibit the dephosphorylation of MLC leading to increased actin-membrane linkage.
    Title: STRIPAK components determine mode of cancer cell migration and metastasis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14743, KIAA1761, MGC148091, RP4-773N10.1, 6330569M22Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
striatin-interacting protein 1
Names
FAR11 factor arrest 11 homolog A
family with sequence similarity 40, member A
homolog of yeast FAR11 protein 1
protein FAM40A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270768.2 → NP_001257697.1  striatin-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001257697.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK027649, AL772411, BC040142
    Consensus CDS
    CCDS59197.1
    UniProtKB/TrEMBL
    A8K4U4
    Related
    ENSP00000358811.1, ENST00000369796.5
    Conserved Domains (2) summary
    pfam07923
    Location:2 → 231
    N1221; N1221-like protein
    pfam11882
    Location:365 → 688
    DUF3402; Domain of unknown function (DUF3402)

  2. NM_033088.4 → NP_149079.2  striatin-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_149079.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB051548, BC040142, CB960147
    Consensus CDS
    CCDS30798.1
    UniProtKB/Swiss-Prot
    Q0V925, Q5VSL8, Q5VSL9, Q658K2, Q6ZV31, Q8N598, Q96SN2, Q9C0A2
    UniProtKB/TrEMBL
    A8K4U4
    Related
    ENSP00000358810.3, ENST00000369795.8
    Conserved Domains (2) summary
    pfam07923
    Location:66 → 336
    N1221; N1221-like protein
    pfam11882
    Location:460 → 783
    DUF3402; Domain of unknown function (DUF3402)

RNA

  1. NR_073071.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL834196, BC040142, DB460380
    Related
    ENST00000485775.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    110031577..110054641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432935.1 → XP_047288891.1  striatin-interacting protein 1 isoform X2

  2. XM_006710995.3 → XP_006711058.1  striatin-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    Q8WUN4
    Conserved Domains (1) summary
    pfam11882
    Location:154 → 477
    DUF3402; Domain of unknown function (DUF3402)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    110041710..110064768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339317.1 → XP_054195292.1  striatin-interacting protein 1 isoform X2

  2. XM_054339316.1 → XP_054195291.1  striatin-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    Q8WUN4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VSL9.1 GenPept UniProtKB/Swiss-Prot:Q5VSL9

Gene LinkOut

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