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GLG1 glycogenin glucosyltransferase GLG1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853932, updated on 1-Aug-2024

Summary

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Gene symbol
GLG1
Gene description
glycogenin glucosyltransferase GLG1
Primary source
FungiDB:YKR058W
Locus tag
YKR058W
See related
SGD:S000001766; AllianceGenome:SGD:S000001766; VEuPathDB:YKR058W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glycogenin glucosyltransferase activity. Involved in glycogen biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease XV. Orthologous to several human genes including GYG1 (glycogenin 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GLG1 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (552770..554620)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA (uracil(54)-C(5))-methyltransferase Neighboring gene ribosomal 40S subunit protein S21A Neighboring gene translation initiation factor eIF4A Neighboring gene Utp30p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Initiation of glycogen synthesis in yeast. Requirement of multiple tyrosine residues for function of the self-glucosylating Glg proteins in vivo. Mu J, et al. J Biol Chem, 1996 Oct 25. PMID 8900126
  2. Dynamic responses of reserve carbohydrate metabolism under carbon and nitrogen limitations in Saccharomyces cerevisiae. Parrou JL, et al. Yeast, 1999 Feb. PMID 10077186
  3. Requirement of the self-glucosylating initiator proteins Glg1p and Glg2p for glycogen accumulation in Saccharomyces cerevisiae. Cheng C, et al. Mol Cell Biol, 1995 Dec. PMID 8524228, Free PMC Article
  4. Multi-gene phylogenetic analysis reveals that shochu-fermenting Saccharomyces cerevisiae strains form a distinct sub-clade of the Japanese sake cluster. Futagami T, et al. Yeast, 2017 Oct. PMID 28703391
  5. Role of reserve carbohydrates in the growth dynamics of Saccharomyces cerevisiae. Guillou V, et al. FEMS Yeast Res, 2004 Sep. PMID 15450184

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycogenin glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycogenin glucosyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glycogenin glucosyltransferase GLG1
NP_012984.2
  • Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole respectively; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    552770..554620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179848.1 → NP_012984.2  TPA: glycogenin glucosyltransferase GLG1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012984.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXB9, P36143
    UniProtKB/TrEMBL
    G2WI86, N1P2Q9
    Conserved Domains (2) summary
    cd02537
    Location:6 → 279
    GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
    NF033845
    Location:295 → 587
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36143.4

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