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DSC2 Dsc2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854081, updated on 1-Aug-2024

Summary

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Gene symbol
DSC2
Gene description
Dsc2p
Primary source
FungiDB:YOL073C
Locus tag
YOL073C
See related
SGD:S000005434; AllianceGenome:SGD:S000005434; VEuPathDB:YOL073C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Located in endoplasmic reticulum. Part of Dsc E3 ubiquitin ligase complex. Orthologous to human UBAC2 (UBA domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DSC2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (193832..194800, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mdm20p Neighboring gene uncharacterized protein Neighboring gene Thp1p Neighboring gene succinate dehydrogenase assembly factor SDH5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sorting of a multi-subunit ubiquitin ligase complex in the endolysosome system. Yang X, et al. Elife, 2018 Jan 22. PMID 29355480, Free PMC Article
  2. Identification of candidate substrates for the Golgi Tul1 E3 ligase using quantitative diGly proteomics in yeast. Tong Z, et al. Mol Cell Proteomics, 2014 Nov. PMID 25078903, Free PMC Article
  3. TOR complex 2 (TORC2) signaling and the ESCRT machinery cooperate in the protection of plasma membrane integrity in yeast. Schmidt O, et al. J Biol Chem, 2020 Aug 21. PMID 32611771, Free PMC Article
  4. Membrane-anchored ubiquitin ligase complex is required for the turnover of lysosomal membrane proteins. Li M, et al. J Cell Biol, 2015 Nov 9. PMID 26527740, Free PMC Article
  5. Starvation-Dependent Regulation of Golgi Quality Control Links the TOR Signaling and Vacuolar Protein Sorting Pathways. Dobzinski N, et al. Cell Rep, 2015 Sep 22. PMID 26344761

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of Dsc E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dsc2p
NP_014568.1
  • Multi-transmembrane subunit of the DSC ubiquitin ligase complex; similar in sequence to rhomboid pseudoproteases Der1p and UBAC2 that function in ERAD; ortholog of fission yeast dsc2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    193832..194800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183328.1 → NP_014568.1  TPA: Dsc2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014568.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1Z4, Q08232
    UniProtKB/TrEMBL
    A6ZND7, B3LIY7, B5VRI0, C7GK40, N1NWD2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08232.1

Gene LinkOut

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