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NUF2 kinetochore-associated Ndc80 complex subunit NUF2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854085, updated on 1-Aug-2024

Summary

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Gene symbol
NUF2
Gene description
kinetochore-associated Ndc80 complex subunit NUF2
Primary source
FungiDB:YOL069W
Locus tag
YOL069W
See related
SGD:S000005430; AllianceGenome:SGD:S000005430; VEuPathDB:YOL069W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to microtubule binding activity. Involved in chromosome segregation. Located in kinetochore; spindle microtubule; and spindle pole body. Part of Ndc80 complex. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NUF2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (198942..200297)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase assembly factor SDH5 Neighboring gene Nba1p Neighboring gene histone deacetylase HST1 Neighboring gene Rtg1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuf2, a spindle pole body-associated protein required for nuclear division in yeast. Osborne MA, et al. J Cell Biol, 1994 May. PMID 8188751, Free PMC Article
  2. Coupling unbiased mutagenesis to high-throughput DNA sequencing uncovers functional domains in the Ndc80 kinetochore protein of Saccharomyces cerevisiae. Tien JF, et al. Genetics, 2013 Sep. PMID 23833183, Free PMC Article
  3. RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure. Schmitzberger F, et al. EMBO Rep, 2012 Mar 1. PMID 22322944, Free PMC Article
  4. The Ndc80 loop region facilitates formation of kinetochore attachment to the dynamic microtubule plus end. Maure JF, et al. Curr Biol, 2011 Feb 8. PMID 21256019, Free PMC Article
  5. Architecture and flexibility of the yeast Ndc80 kinetochore complex. Wang HW, et al. J Mol Biol, 2008 Nov 21. PMID 18793650, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface.
    Title: Structure of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in kinetochore organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Ndc80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ndc80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Ndc80 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Ndc80 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinetochore-associated Ndc80 complex subunit NUF2
NP_014572.1
  • Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    198942..200297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183324.1 → NP_014572.1  TPA: kinetochore-associated Ndc80 complex subunit NUF2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014572.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1Z8, P33895, Q6B1X5
    UniProtKB/TrEMBL
    A6ZNE1, B5VRI3, C7GK36, G2WMG5, N1NWD5
    Conserved Domains (2) summary
    COG1196
    Location:182 → 421
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03800
    Location:5 → 148
    Nuf2; Nuf2 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33895.1

Gene LinkOut

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