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RPP2A ribosomal protein P2A [ Saccharomyces cerevisiae S288C ]

Gene ID: 854118, updated on 3-Nov-2024

Summary

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Official Symbol
RPP2A
Official Full Name
ribosomal protein P2A
Primary source
SGD:S000005399
Locus tag
YOL039W
See related
AllianceGenome:SGD:S000005399; FungiDB:YOL039W; VEuPathDB:YOL039W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RPL44; RPLA2
Summary
A structural constituent of ribosome. Involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Orthologous to human RPLP2 (ribosomal protein lateral stalk subunit P2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RPP2A in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (254297..254617)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Nop12p Neighboring gene ribosomal 40S subunit protein S15 Neighboring gene uncharacterized protein Neighboring gene proteasome core particle subunit alpha 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of single-copy genes encoding acidic ribosomal proteins in Saccharomyces cerevisiae. Remacha M, et al. Mol Cell Biol, 1990 May. PMID 2183022, Free PMC Article
  2. Characterization of the yeast acidic ribosomal phosphoproteins using monoclonal antibodies. Proteins L44/L45 and L44' have different functional roles. Vilella MD, et al. Eur J Biochem, 1991 Mar 14. PMID 1706664
  3. Temporal genetic association and temporal genetic causality methods for dissecting complex networks. Lin L, et al. Nat Commun, 2018 Sep 28. PMID 30266904, Free PMC Article
  4. Independent genes coding for three acidic proteins of the large ribosomal subunit from Saccharomyces cerevisiae. Remacha M, et al. J Biol Chem, 1988 Jul 5. PMID 2837476
  5. Stable binding of the eukaryotic acidic phosphoproteins to the ribosome is not an absolute requirement for in vivo protein synthesis. Remacha M, et al. J Biol Chem, 1992 Jun 15. PMID 1601875

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P1/P2 heterodimers bind to P0 when both ribosomal subunits are joined and committed to translation, and they detached from the stalk, just after the small and large ribosomal subunits were separated from the mRNA.
    Title: The P1/P2 protein heterodimers assemble to the ribosomal stalk at the moment when the ribosome is committed to translation but not to the native 60S ribosomal subunit in Saccharomyces cerevisiae.
  2. The reported results support that while most ribosomes contain a P1alpha/P2beta-P0-P1beta/P2alpha structure in normal conditions, the stalk assembly mechanism can generate alternative compositions, which have been previously detected in the cell.
    Title: P1 and P2 protein heterodimer binding to the P0 protein of Saccharomyces cerevisiae is relatively non-specific and a source of ribosomal heterogeneity.
  3. The authors have found that neither P1 nor P2 directly interact with P0 unless the endogenous heterodimer partner is being expressed in the cell.
    Title: In vivo formation of a stable pentameric (P2alpha/P1beta)-P0-(P1alpha/P2beta) ribosomal stalk complex in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal protein P2A
NP_014603.1
  • Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    254297..254617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183293.1 → NP_014603.1  TPA: ribosomal protein P2A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014603.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W227, P05319
    UniProtKB/TrEMBL
    A6ZNH0, B3LJ19, C7GK08, C8ZHS5, G2WMJ4, N1NVP6
    Conserved Domains (1) summary
    cd05833
    Location:15 → 106
    Ribosomal_P2; Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05319.1

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