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UTP23 rRNA-binding ribosome biosynthesis protein UTP23 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854165, updated on 17-May-2024

Summary

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Gene symbol
UTP23
Gene description
rRNA-binding ribosome biosynthesis protein UTP23
Primary source
FungiDB:YOR004W
Locus tag
YOR004W
See related
SGD:S000005530; AllianceGenome:SGD:S000005530; VEuPathDB:YOR004W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables small ribosomal subunit rRNA binding activity. Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of small-subunit processome. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human UTP23 (UTP23 small subunit processome component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See UTP23 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (333592..334356)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase Neighboring gene putative subtilisin-like protease YSP3 Neighboring gene DNA ligase (ATP) DNL4 Neighboring gene ribosome biogenesis protein TSR3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional analysis of Utp23, a yeast ribosome synthesis factor with degenerate PIN domain. Lu J, et al. RNA, 2013 Dec. PMID 24152547, Free PMC Article
  2. Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Wu LF, et al. Nat Genet, 2002 Jul. PMID 12089522
  3. Synergistic interaction network between the snR30 RNP, Utp23, and ribosomal RNA during ribosome synthesis. Vos TJ, et al. RNA Biol, 2022 Jan. PMID 35648701, Free PMC Article
  4. The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Bleichert F, et al. Proc Natl Acad Sci U S A, 2006 Jun 20. PMID 16769905, Free PMC Article
  5. Utp23p is required for dissociation of snR30 small nucleolar RNP from preribosomal particles. Hoareau-Aveilla C, et al. Nucleic Acids Res, 2012 Apr. PMID 22180534, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synergistic interaction network between the snR30 RNP, Utp23, and ribosomal RNA during ribosome synthesis.
    Title: Synergistic interaction network between the snR30 RNP, Utp23, and ribosomal RNA during ribosome synthesis.
  2. yUtp23/hUTP23 could therefore be central to the coordinated integration and release of ES6 binding factors and likely plays a pivotal role in remodeling this pre-rRNA region in both yeast and humans. Finally, studies using RNAi-rescue systems in human cells revealed that intact PIN domain and Zinc finger motifs in human hUTP23 are essential for 18S rRNA maturation.
    Title: The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in the yeast and human pre-40S particle and hUTP23 contains an essential PIN domain.
  3. The Zn-finger motif is required for Utp23 structure or function.
    Title: Structural and functional analysis of Utp23, a yeast ribosome synthesis factor with degenerate PIN domain.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables small ribosomal subunit rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small ribosomal subunit rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small ribosomal subunit rRNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of small-subunit processome IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
rRNA-binding ribosome biosynthesis protein UTP23
NP_014646.1
  • Component of the small subunit processome; involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    333592..334356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183423.1 → NP_014646.1  TPA: rRNA-binding ribosome biosynthesis protein UTP23 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014646.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W270, Q12339
    UniProtKB/TrEMBL
    A0A7I9GC77, A6ZNK9, B3LJ59, B5VRQ6, C7GJU9, C8ZHW7, G2WMN4, N1NWE9
    Conserved Domains (1) summary
    cd09865
    Location:3 → 150
    PIN_ScUtp23p-like; VapC-like PIN domain of rRNA-processing protein, Utp23 (YOR004W), and other fungal homologs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12339.1

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