U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

YNG1 Yng1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854230, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
YNG1
Official Full Name
Yng1p
Primary source
SGD:S000005590
Locus tag
YOR064C
See related
AllianceGenome:SGD:S000005590; FungiDB:YOR064C; VEuPathDB:YOR064C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YOR29-15
Summary
Enables methylated histone binding activity. Contributes to histone acetyltransferase activity. Involved in chromatin organization; histone acetylation; and positive regulation of transcription elongation from RNA polymerase II promoter. Part of NuA3a histone acetyltransferase complex. Orthologous to human ING2 (inhibitor of growth family member 2) and ING5 (inhibitor of growth family member 5). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See YNG1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (446079..446738, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L3 Neighboring gene ubiquinol--cytochrome-c reductase catalytic subunit CYT1 Neighboring gene Msa1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ING3 is required for ATM signaling and DNA repair in response to DNA double strand breaks. Mouche A, et al. Cell Death Differ, 2019 Nov. PMID 30804473, Free PMC Article
  2. Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Taverna SD, et al. Mol Cell, 2006 Dec 8. PMID 17157260, Free PMC Article
  3. Yng1p modulates the activity of Sas3p as a component of the yeast NuA3 Hhistone acetyltransferase complex. Howe L, et al. Mol Cell Biol, 2002 Jul. PMID 12077334, Free PMC Article
  4. Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Loewith R, et al. Mol Cell Biol, 2000 Jun. PMID 10805724, Free PMC Article
  5. Histone H3K4 and H3K36 Methylation Independently Recruit the NuA3 Histone Acetyltransferase in Saccharomyces cerevisiae. Martin BJ, et al. Genetics, 2017 Mar. PMID 28108585, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics.
    Title: NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics.
  2. The conserved yeast histone acetyltransferase complex, NuA3, specifically binds H3K4me3 through a plant homeodomain finger in the Yng1 subunit, and subsequently catalyzes the acetylation of H3K14 through the histone acetyltransferase domain of Sas3.
    Title: A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions.
  3. These results identify a novel function for the Yng1p PHD finger in promoting stabilization of the NuA3 complex at chromatin through recognition of histone H3 lysine 4 methylation.
    Title: The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3.
  4. Disrupting the K4me3 binding of Yng1 altered K14ac and transcription at certain genes, thereby demonstrating direct in vivo evidence of sequential trimethyl binding, acetyltransferase activity, and gene regulation by NuA3.
    Title: Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to histone acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated histone binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NuA3 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NuA3 histone acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of NuA3a histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Yng1p
NP_014707.1
  • Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; shares significant sequence identity with the human candidate tumor suppressor p33-ING1 in C-terminal region

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    446079..446738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183483.1 → NP_014707.1  TPA: Yng1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014707.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2C7, O00025, Q08465
    UniProtKB/TrEMBL
    A6ZNR6, B3LJB3, C7GX54, G2WMU2, N1NYB0
    Conserved Domains (1) summary
    COG5034
    Location:1 → 206
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08465.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.