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MTR10 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854331, updated on 22-Aug-2024

Summary

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Official Symbol
MTR10
Primary source
SGD:S000005686
Locus tag
YOR160W
See related
AllianceGenome:SGD:S000005686; FungiDB:YOR160W; VEuPathDB:YOR160W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KAP111
Summary
Enables nuclear localization sequence binding activity. Involved in protein import into nucleus; snRNA import into nucleus; and tRNA transport. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 2. Orthologous to human TNPO3 (transportin 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (633839..636757)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein PET123 Neighboring gene mRNA splicing protein SME1 Neighboring gene Pns1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Retrograde movement of tRNAs from the cytoplasm to the nucleus in Saccharomyces cerevisiae. Shaheen HH, et al. Proc Natl Acad Sci U S A, 2005 Aug 9. PMID 16040803, Free PMC Article
  2. Biogenesis of yeast telomerase depends on the importin mtr10. Ferrezuelo F, et al. Mol Cell Biol, 2002 Sep. PMID 12167699, Free PMC Article
  3. Genome-wide investigation of the role of the tRNA nuclear-cytoplasmic trafficking pathway in regulation of the yeast Saccharomyces cerevisiae transcriptome and proteome. Chu HY, et al. Mol Cell Biol, 2013 Nov. PMID 23979602, Free PMC Article
  4. Importin-beta family members mediate alpharetrovirus gag nuclear entry via interactions with matrix and nucleocapsid. Butterfield-Gerson KL, et al. J Virol, 2006 Feb. PMID 16439536, Free PMC Article
  5. Identification of Gbp2 as a novel poly(A)+ RNA-binding protein involved in the cytoplasmic delivery of messenger RNAs in yeast. Windgassen M, et al. EMBO Rep, 2003 Mar. PMID 12634846, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Npl3p, Gbp2p, and Hrb1p are part of the S. cerevisiae translating mRNPs, and Npl3p is regulated by Mtr10p and can function as a translational repressor
    Title: Yeast shuttling SR proteins Npl3p, Gbp2p, and Hrb1p are part of the translating mRNPs, and Npl3p can function as a translational repressor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables nuclear localization sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snRNA import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear periphery HDA PubMed 
located_in nuclear periphery HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mtr10p
NP_014803.1
  • Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    633839..636757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183579.1 → NP_014803.1  TPA: Mtr10p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014803.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2L7, Q99189
    UniProtKB/TrEMBL
    A6ZP04, N1P395
    Conserved Domains (2) summary
    smart00913
    Location:28 → 97
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:100 → 253
    Xpo1; Exportin 1-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99189.1

Gene LinkOut

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