HIS3 imidazoleglycerol-phosphate dehydratase HIS3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: HIS3
Gene description: imidazoleglycerol-phosphate dehydratase HIS3
Primary source: FungiDB:YOR202W
Locus tag: YOR202W
See related: SGD:S000005728; AllianceGenome:SGD:S000005728; VEuPathDB:YOR202W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HIS10; HIS8
Summary: Enables imidazoleglycerol-phosphate dehydratase activity. Involved in histidine biosynthetic process. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HIS3 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (721946..722608)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The structure of Sc_IGPD reveals that a 24-amino acid insertion forms an extended loop region on the enzyme surface that lies adjacent to the active site, forming interactions with the substrate/inhibitor binding loop that may influence inhibitor potency.
Title: Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.
Snf1 protein is important for HIS3 expression
Title: Histone H3 Ser10 phosphorylation-independent function of Snf1 and Reg1 proteins rescues a gcn5- mutant in HIS3 expression.
We propose that Gcn4p stimulates nucleosome mobilization over the entire HIS3 gene by the SWI/SNF complex. We suggest that the net effect of interplay among remodeling machines at HIS3 is to create a highly dynamic chromatin structure.
Title: Activation of Saccharomyces cerevisiae HIS3 results in Gcn4p-dependent, SWI/SNF-dependent mobilization of nucleosomes over the entire gene.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables imidazoleglycerol-phosphate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables imidazoleglycerol-phosphate dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables imidazoleglycerol-phosphate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables imidazoleglycerol-phosphate dehydratase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-histidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-histidine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-histidine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-histidine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: imidazoleglycerol-phosphate dehydratase HIS3

NP_014845.1

EC 4.2.1.19

Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

721946..722608

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183621.1 → NP_014845.1 TPA: imidazoleglycerol-phosphate dehydratase HIS3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014845.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2Q9, P06633, Q12695, Q70D78, Q70D79, Q70D81, Q70D83

UniProtKB/TrEMBL

A6ZP46, B5VS85, C7GWH9, C8ZGV8, G2WN75, N1NYM2

Conserved Domains (1) summary

COG0131
Location:1 → 219

HisB2; Imidazoleglycerol phosphate dehydratase HisB [Amino acid transport and metabolism]