U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RFM1 Rfm1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854453, updated on 29-Jun-2024

Summary

Go to the top of the page Help
Gene symbol
RFM1
Gene description
Rfm1p
Primary source
FungiDB:YOR279C
Locus tag
YOR279C
See related
SGD:S000005805; AllianceGenome:SGD:S000005805; VEuPathDB:YOR279C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein-macromolecule adaptor activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of DNA-dependent DNA replication initiation. Part of histone deacetylase complex. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RFM1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (843698..844630, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uroporphyrinogen-III synthase HEM4 Neighboring gene putative serine hydrolase Neighboring gene Plp2p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Interaction trap experiment with CDC6. Zavec PB, et al. Pflugers Arch, 2000 Jan. PMID 28176084
  2. The duplicated deacetylases Sir2 and Hst1 subfunctionalized by acquiring complementary inactivating mutations. Froyd CA, et al. Mol Cell Biol, 2011 Aug. PMID 21690292, Free PMC Article
  3. The Srs2 helicase dampens DNA damage checkpoint by recycling RPA from chromatin. Dhingra N, et al. Proc Natl Acad Sci U S A, 2021 Feb 23. PMID 33602817, Free PMC Article
  4. Rfm1, a novel tethering factor required to recruit the Hst1 histone deacetylase for repression of middle sporulation genes. McCord R, et al. Mol Cell Biol, 2003 Mar. PMID 12612074, Free PMC Article
  5. Cdc7-Dbf4 is a gene-specific regulator of meiotic transcription in yeast. Lo HC, et al. Mol Cell Biol, 2012 Jan. PMID 22106412, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated DNA replication initiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of histone deacetylase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Rfm1p
NP_014922.3
  • Component of the Sum1p-Rfm1p-Hst1p complex; Rfm1p tethers the Hst1p histone deacetylase to the DNA-binding protein Sum1p; complex is involved in transcriptional repression of middle sporulation genes and in initiation of DNA replication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    843698..844630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183698.3 → NP_014922.3  TPA: Rfm1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014922.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2X8, Q12192
    UniProtKB/TrEMBL
    A0A8H4FAG2, B5VSF9, C8ZH29, N1NWW9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12192.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools