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gag-pol fusion protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 854523, updated on 14-Nov-2024

Summary

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Official Full Name
gag-pol fusion protein
Primary source
SGD:S000007356
Locus tag
YOR343W-B
See related
AllianceGenome:SGD:S000007356; FungiDB:YOR343W-B; VEuPathDB:YOR343W-B
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YOR343C-B
Summary
Predicted to enable several functions, including DNA polymerase activity; RNA nuclease activity; and peptidase activity. Predicted to be involved in retrotransposition. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (970578..975891)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene gag protein Neighboring gene tRNA-Met Neighboring gene Tye7p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Invading the yeast nucleus: a nuclear localization signal at the C terminus of Ty1 integrase is required for transposition in vivo. Kenna MA, et al. Mol Cell Biol, 1998 Feb. PMID 9448009, Free PMC Article
  2. Ty1 gag enhances the stability and nuclear export of Ty1 mRNA. Checkley MA, et al. Traffic, 2013 Jan. PMID 22998189, Free PMC Article
  3. Happy together: the life and times of Ty retrotransposons and their hosts. Lesage P, et al. Cytogenet Genome Res, 2005. PMID 16093660
  4. Evolutionary genomics of transposable elements in Saccharomyces cerevisiae. Carr M, et al. PLoS One, 2012. PMID 23226439, Free PMC Article
  5. Transposable elements and genome organization: a comprehensive survey of retrotransposons revealed by the complete Saccharomyces cerevisiae genome sequence. Kim JM, et al. Genome Res, 1998 May. PMID 9582191

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA nuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA-DNA hybrid ribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables telomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA integration IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA-templated DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in retrotransposition ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transposition IEA
Inferred from Electronic Annotation
more info
  
involved_in viral translational frameshifting IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in retrotransposon nucleocapsid ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
gag-pol fusion protein
NP_620389.3
  • Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    970578..975891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184390.4 → NP_620389.3  TPA: gag-pol fusion protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_620389.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W338, Q12501
    Conserved Domains (5) summary
    cd09272
    Location:1621 → 1757
    RNase_HI_RT_Ty1; Ty1/Copia family of RNase HI in long-term repeat retroelements
    pfam00665
    Location:660 → 778
    rve; Integrase core domain
    pfam01021
    Location:17 → 114
    TYA; TYA transposon protein
    pfam07727
    Location:1296 → 1489
    RVT_2; Reverse transcriptase (RNA-dependent DNA polymerase)
    pfam13976
    Location:574 → 641
    gag_pre-integrs; GAG-pre-integrase domain
Nucleotide Protein
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