TYE7 Tye7p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: TYE7
Gene description: Tye7p
Primary source: FungiDB:YOR344C
Locus tag: YOR344C
See related: SGD:S000005871; AllianceGenome:SGD:S000005871; VEuPathDB:YOR344C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SGC1
Summary: Enables DNA-binding transcription factor activity. Involved in positive regulation of glycolytic process and transcription elongation from RNA polymerase II promoter. Located in chromatin. Human ortholog(s) of this gene implicated in cardiovascular system disease; disease of metabolism; and type 2 diabetes mellitus. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1) and USF1 (upstream transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Ty1 activation in response to adenylic nucleotide depletion requires the DNA-binding transcription factor Tye7.
Title: Tye7 regulates yeast Ty1 retrotransposon sense and antisense transcription in response to adenylic nucleotides stress.
Tye7 is a metabolic targets of Skp1-Cul1-F-box (SCF) ubiquitin ligase.
Title: A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of glycolytic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_014989.3

Serine-rich protein that contains a bHLH DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression; bHLH stands for basic-helix-loop-helix

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The following sections contain reference sequences that belong to a specific genome build. Explain