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SNX3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854539, updated on 11-Sep-2024

Summary

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Official Symbol
SNX3
Primary source
SGD:S000005884
Locus tag
YOR357C
See related
AllianceGenome:SGD:S000005884; FungiDB:YOR357C; VEuPathDB:YOR357C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GRD19
Summary
Enables phosphatidylinositol-3-phosphate binding activity. Involved in late endosome to Golgi transport and protein localization. Located in cytosol and endosome. Human ortholog(s) of this gene implicated in syndromic microphthalmia 8. Orthologous to human SNX12 (sorting nexin 12) and SNX3 (sorting nexin 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (1009224..1009712, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Gds1p Neighboring gene putative electron-transferring-flavoprotein dehydrogenase Neighboring gene Hap5p Neighboring gene Vts1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Retrieval of resident late-Golgi membrane proteins from the prevacuolar compartment of Saccharomyces cerevisiae is dependent on the function of Grd19p. Voos W, et al. J Cell Biol, 1998 Feb 9. PMID 9456318, Free PMC Article
  2. α-synuclein inhibits Snx3-retromer retrograde trafficking of the conserved membrane-bound proprotein convertase Kex2 in the secretory pathway of Saccharomyces cerevisiae. Rajasekaran S, et al. Hum Mol Genet, 2022 Mar 3. PMID 34570221, Free PMC Article
  3. Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling. Strochlic TI, et al. J Cell Biol, 2007 Apr 9. PMID 17420293, Free PMC Article
  4. Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease. Patel D, et al. Hum Mol Genet, 2018 May 1. PMID 29452354
  5. Structural features of vps35p involved in interaction with other subunits of the retromer complex. Restrepo R, et al. Traffic, 2007 Dec. PMID 17892535, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3-phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosome to Golgi transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of retromer complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Snx3p
NP_015002.3
  • Sorting nexin for late-Golgi enzymes; required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    1009224..1009712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183777.3 → NP_015002.3  TPA: Snx3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015002.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W352, Q08826
    UniProtKB/TrEMBL
    A6ZPI7, B3LK14, B5VSN5, C7GNR1, C8ZHA7, G2WNL8, N1NXJ1
    Conserved Domains (1) summary
    cd07295
    Location:35 → 160
    PX_Grd19; The phosphoinositide binding Phox Homology domain of fungal Grd19
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08826.1

Gene LinkOut

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