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PRT1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854543, updated on 11-Sep-2024

Summary

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Official Symbol
PRT1
Primary source
SGD:S000005888
Locus tag
YOR361C
See related
AllianceGenome:SGD:S000005888; FungiDB:YOR361C; VEuPathDB:YOR361C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDC63; DNA26
Summary
Enables translation initiation factor activity. Involved in cytoplasmic translational initiation. Located in cytoplasmic stress granule. Part of eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; and multi-eIF complex. Orthologous to human EIF3B (eukaryotic translation initiation factor 3 subunit B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (1015361..1017652, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Vts1p Neighboring gene 3',5'-cyclic-nucleotide phosphodiesterase PDE2 Neighboring gene proteasome core particle subunit alpha 7 Neighboring gene oleate-activated transcription factor PIP2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of a protein complex containing translation initiation factor Prt1 from Saccharomyces cerevisiae. Danaie P, et al. J Biol Chem, 1995 Mar 3. PMID 7876188
  2. Mutational analysis of the Prt1 protein subunit of yeast translation initiation factor 3. Evans DR, et al. Mol Cell Biol, 1995 Aug. PMID 7623843, Free PMC Article
  3. Mapping CDC mutations in the yeast S. cerevisiae by rad52-mediated chromosome loss. Hanic-Joyce PJ. Genetics, 1985 Aug. PMID 3896925, Free PMC Article
  4. Regulated arrest of cell proliferation mediated by yeast prt1 mutations. Hanic-Joyce PJ, et al. Exp Cell Res, 1987 Sep. PMID 3308493
  5. Molecular characterization of the yeast PRT1 gene in which mutations affect translation initiation and regulation of cell proliferation. Hanic-Joyce PJ, et al. J Biol Chem, 1987 Feb 25. PMID 3029094

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast eIF3b exhibits RNA binding activity but huamn eIF3b doesn't.
    Title: Crystal structure of the RNA recognition motif of yeast translation initiation factor eIF3b reveals differences to human eIF3b.
  2. Data suggest that the eIF3b-eIF3j/eIF3a module binds near the mRNA entry channel and regulates the transition between scanning-conducive and initiation-competent conformations of the preinitiation complex.
    Title: The C-terminal region of eukaryotic translation initiation factor 3a (eIF3a) promotes mRNA recruitment, scanning, and, together with eIF3j and the eIF3b RNA recognition motif, selection of AUG start codons.
  3. eIF3j/HCR1 closely cooperates with the eIF3b/PRT1 RNA recognition motif and eIF1A on the ribosome to ensure proper formation of the scanning-arrested conformation required for stringent AUG recognition
    Title: The indispensable N-terminal half of eIF3j/HCR1 cooperates with its structurally conserved binding partner eIF3b/PRT1-RRM and with eIF1A in stringent AUG selection.
  4. Interaction of the RNP1 motif in PRT1 with HCR1 promotes 40S binding of eIF3.
    Title: Interaction of the RNP1 motif in PRT1 with HCR1 promotes 40S binding of eukaryotic initiation factor 3 in yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of multi-eIF complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
translation initiation factor eIF3 core subunit b
NP_015006.3
  • eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; eIF3 is also involved in programmed stop codon readthrough

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    1015361..1017652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183781.3 → NP_015006.3  TPA: translation initiation factor eIF3 core subunit b [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015006.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZPJ1, D6W356, P06103
    UniProtKB/TrEMBL
    B3LK18, B5VSN9, C8ZHA9
    Conserved Domains (2) summary
    COG5354
    Location:200 → 746
    COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
    cd12278
    Location:76 → 158
    RRM_eIF3B; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06103.1

Gene LinkOut

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