U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PIP2 oleate-activated transcription factor PIP2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854545, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
PIP2
Official Full Name
oleate-activated transcription factor PIP2
Primary source
SGD:S000005890
Locus tag
YOR363C
See related
AllianceGenome:SGD:S000005890; FungiDB:YOR363C; VEuPathDB:YOR363C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
OAF2
Summary
Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of fatty acid beta-oxidation and positive regulation of transcription from RNA polymerase II promoter by oleic acid. Part of Pip2-Oaf1 complex. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PIP2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (1020222..1023212, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF3 core subunit b Neighboring gene proteasome core particle subunit alpha 7 Neighboring gene putative flavin adenine dinucleotide transporter Neighboring gene Scp1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Correlative AFM and fluorescence imaging demonstrate nanoscale membrane remodeling and ring-like and tubular structure formation by septins. Vial A , et al. Nanoscale, 2021 Aug 7. PMID 34225356
  2. Pip2p: a transcriptional regulator of peroxisome proliferation in the yeast Saccharomyces cerevisiae. Rottensteiner H, et al. EMBO J, 1996 Jun 17. PMID 8670793, Free PMC Article
  3. Integrated phosphoproteomics analysis of a signaling network governing nutrient response and peroxisome induction. Saleem RA, et al. Mol Cell Proteomics, 2010 Sep. PMID 20395639, Free PMC Article
  4. Fungi and animals may share a common ancestor to nuclear receptors. Phelps C, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16636289, Free PMC Article
  5. Saccharomyces cerevisiae Pip2p-Oaf1p regulates PEX25 transcription through an adenine-less ORE. Rottensteiner H, et al. Eur J Biochem, 2003 May. PMID 12709061

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We thus uncover a meiotic functional role for TAO3, and identify ERT1 and PIP2 as novel regulators of sporulation efficiency. Our results demonstrate that studying the causal effects of genetic variation on the underlying molecular network has the potential to provide a more extensive understanding of the pathways driving a complex trait
    Title: Meiotic Interactors of a Mitotic Gene TAO3 Revealed by Functional Analysis of its Rare Variant.
  2. Data indicate that Oaf1p, Pip2p and Adr1p are required for the initial binding of Oaf3p before oleate induction.
    Title: Role of the repressor Oaf3p in the recruitment of transcription factors and chromatin dynamics during the oleate response.
  3. In the absence of Pip2, Oaf1 may form homodimers.
    Title: Yeast transcription factor Oaf1 forms homodimer and induces some oleate-responsive genes in absence of Pip2.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to oleic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription from RNA polymerase II promoter by oleic acid IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription from RNA polymerase II promoter by oleic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Pip2-Oaf1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Pip2-Oaf1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
oleate-activated transcription factor PIP2
NP_015008.3
  • Autoregulatory, oleate-activated transcription factor; subunit of a heterodimeric complex with Oaf1p, which binds to oleate-response elements (ORE) in the promoter of genes involved in beta-oxidation of fatty acids, peroxisome organization and biogenesis, activating transcription in the presence of oleate; PIP2 has a paralog, OAF1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    1020222..1023212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183783.3 → NP_015008.3  TPA: oleate-activated transcription factor PIP2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015008.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W358, P52960
    UniProtKB/TrEMBL
    A6ZPJ3, B3LK20, N1NZ08
    Conserved Domains (2) summary
    cd12148
    Location:274 → 676
    fungal_TF_MHR; fungal transcription factor regulatory middle homology region
    cd00067
    Location:20 → 55
    GAL4; GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52960.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools