ATP6 F1F0 ATP synthase subunit a [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ATP6
Official Full Name: F1F0 ATP synthase subunit a
Primary source: SGD:S000007268
Locus tag: Q0085
See related: AllianceGenome:SGD:S000007268; FungiDB:Q0085; VEuPathDB:Q0085
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: OLI2; OLI4; PHO1
Summary: Contributes to proton-transporting ATP synthase activity, rotational mechanism. Involved in ATP synthesis coupled proton transport. Located in mitochondrion. Part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Used to study several diseases, including Leigh disease; NARP syndrome; autosomal dominant cerebellar ataxia; endocrine gland cancer (multiple); and prostate cancer. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; NARP syndrome; Parkinson's disease; multiple sclerosis; and systemic lupus erythematosus. Orthologous to human MT-ATP6 (mitochondrially encoded ATP synthase membrane subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ATP6 in Genome Data Viewer

Sequence:: Chromosome: MT; NC_001224.1 (28487..29266)

Chromosome MT - NC_001224.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001224.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mic10 interacts with the dimeric form of mitochondrial F1Fo-ATP synthase.
Title: Mic10, a Core Subunit of the Mitochondrial Contact Site and Cristae Organizing System, Interacts with the Dimeric F(1)F(o)-ATP Synthase.
The T9185C and T9191C ATP synthase two pathogenic human mitochondrial DNA mutations correlate with the severity phenotypes of two mitochondrial human diseases.
Title: Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C.
analysis of the structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae
Title: Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae.
two subunits 6 are close in the inner mitochondrial membrane and in the solubilized supramolecular forms of the yeast ATP synthase.
Title: Evidence of the proximity of ATP synthase subunits 6 (a) in the inner mitochondrial membrane and in the supramolecular forms of Saccharomyces cerevisiae ATP synthase.
Although the oxidative phosphorylation capacity was reduced in atp6-T9176C yeast, the number of ATP molecules synthesized per electron transferred to oxygen was similar compared with wild type yeast.
Title: Consequences of the pathogenic T9176C mutation of human mitochondrial DNA on yeast mitochondrial ATP synthase.
These results establish a mechanism by which expression of ATP6 and ATP8 is translationally regulated by F(1) to achieve a balanced output of two compartmentally separated sets of ATP synthase genes.
Title: F1-dependent translation of mitochondrially encoded Atp6p and Atp8p subunits of yeast ATP synthase.
Mitochondrial morphology is profoundly altered in the human mutant atp6-L247R.
Title: Introducing the human Leigh syndrome mutation T9176G into Saccharomyces cerevisiae mitochondrial DNA leads to severe defects in the incorporation of Atp6p into the ATP synthase and in the mitochondrial morphology.
Yeast cells depleted in Atp14p fail to assemble Atp6p within the ATP synthase and exhibit altered mitochondrial cristae morphology
Title: Yeast cells depleted in Atp14p fail to assemble Atp6p within the ATP synthase and exhibit altered mitochondrial cristae morphology.
presequence either targets Atp6p to the Atp9p or signals insertion of the Atp6p precursor into a microcompartment of the membrane for more efficient interaction with the Atp9p ring.
Title: The leader peptide of yeast Atp6p is required for efficient interaction with the Atp9p ring of the mitochondrial ATPase.
a mutation in mitochondrial F(1)F(0)-ATP synthase prevents the synthesis of the two mtDNA-encoded subunits (Atp6p and Atp9p) forming the core of this channel
Title: A "petite obligate" mutant of Saccharomyces cerevisiae: functional mtDNA is lethal in cells lacking the delta subunit of mitochondrial F1-ATPase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IDA Inferred from Direct Assay more info	PubMed
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven ATP synthesis	IDA Inferred from Direct Assay more info	PubMed
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven ATP synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of proton-transporting ATP synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: F1F0 ATP synthase subunit a

NP_009313.1

Subunit a of the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrially encoded; translation is specifically activated by Atp22p; ATP6 and ATP8 mRNAs are not translated in the absence of the F1 sector of ATPase; mutations in human ortholog MT-ATP6 are associated with neurodegenerative disorders such as Neurogenic Ataxia and Retinitis Pigmentosa (NARP), Leigh syndrome (LS), Charcot-Marie-Tooth (CMT), and ataxia telangiectasia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001224.1 Reference assembly

Range

28487..29266

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_009313.1 F1F0 ATP synthase subunit a (mitochondrion) [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009313.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

A0A0A7P052, P00854, Q95A27

UniProtKB/TrEMBL

A0A0H3WKN0, A0A343UW80, G2HKE3

Conserved Domains (1) summary

TIGR01131
Location:30 → 256

ATP_synt_6_or_A; ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes)