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BAR1 aspartyl protease BAR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854797, updated on 18-Sep-2024

Summary

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Official Symbol
BAR1
Official Full Name
aspartyl protease BAR1
Primary source
SGD:S000001277
Locus tag
YIL015W
See related
AllianceGenome:SGD:S000001277; FungiDB:YIL015W; VEuPathDB:YIL015W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SST1
Summary
Enables aspartic-type endopeptidase activity. Involved in adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion and peptide catabolic process. Located in extracellular region and fungal-type cell wall. Human ortholog(s) of this gene implicated in Alzheimer's disease; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension (multiple); and portal hypertension. Orthologous to human BACE2 (beta-secretase 2) and REN (renin). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BAR1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (322342..324105)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene glucose-induced degradation complex subunit VID28 Neighboring gene Snl1p Neighboring gene tRNA-Asp Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sensory input attenuation allows predictive sexual response in yeast. Banderas A, et al. Nat Commun, 2016 Aug 25. PMID 27557894, Free PMC Article
  2. Modelling of Yeast Mating Reveals Robustness Strategies for Cell-Cell Interactions. Chen W, et al. PLoS Comput Biol, 2016 Jul. PMID 27404800, Free PMC Article
  3. Yeast mating and image-based quantification of spatial pattern formation. Diener C, et al. PLoS Comput Biol, 2014 Jun. PMID 24967739, Free PMC Article
  4. Purification and genetic control of α-pheromone-inactivating glycoproteins in the yeast Saccharomyces cerevisiae. Fujimura H, et al. Curr Genet, 1984 Dec. PMID 24173508
  5. Disentangling signaling gradients generated by equivalent sources. Rappaport N, et al. J Biol Phys, 2012 Mar. PMID 23450187, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results describe the effect of sequence-directed nucleosome disruption on cell-type-specific repression of BAR1 by alpha2/Mcm1 in the yeast genome.
    Title: Effect of sequence-directed nucleosome disruption on cell-type-specific repression by alpha2/Mcm1 in the yeast genome.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to pheromone IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in conjugation with cellular fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to pheromone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in fungal-type cell wall IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aspartyl protease BAR1
NP_012249.1
  • Aspartyl protease secreted to periplasmic space of mating type a cell; helps cells monitor availability of mating partners; cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    322342..324105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179365.1 → NP_012249.1  TPA: aspartyl protease BAR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012249.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVR4, P12630
    UniProtKB/TrEMBL
    B3LTM3, B5VKS5, C7GSF7, C8ZAN5, N1P965
    Conserved Domains (1) summary
    cd05474
    Location:43 → 395
    SAP_like; SAPs, pepsin-like proteinases secreted from pathogens to degrade host proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12630.1

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