FLO11 Flo11p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: FLO11
Gene description: Flo11p
Primary source: FungiDB:YIR019C
Locus tag: YIR019C
See related: SGD:S000001458; AllianceGenome:SGD:S000001458; VEuPathDB:YIR019C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MUC1; STA4
Summary: Involved in several processes, including invasive growth in response to glucose limitation; pseudohyphal growth; and single-species biofilm formation. Located in cellular bud neck; extracellular region; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FLO11 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (389572..393675, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation in pH gradients and FLO11 expression in mat biofilms from environmental isolates of the yeast Saccharomyces cerevisiae.
Title: Variation in pH gradients and FLO11 expression in mat biofilms from environmental isolates of the yeast Saccharomyces cerevisiae.
The dual role of amyloid-beta-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae.
Title: The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae.
Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family.
Title: Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family.
Cell Distribution within Yeast Colonies and Colony Biofilms: How Structure Develops.
Title: Cell Distribution within Yeast Colonies and Colony Biofilms: How Structure Develops.
Study provides clear evidence of the functions of the Tup1p and Cyc8p regulators in biofilm colony formation. Cyc8p itself is a repressor of FLO11 gene expression and of the formation of the structured architecture of colony biofilms, whereas Tup1p counteracts Cyc8p, being a positive regulator of FLO11 expression and colony complexity.
Title: Cyc8p and Tup1p transcription regulators antagonistically regulate Flo11p expression and complexity of yeast colony biofilms.
by deleting many of the known transcriptional activators of invasion, as well as the gene encoding the cell surface protein Flo11 from five relevant segregants and showing that these individuals differ in the genes they require for invasion
Title: Regulatory Rewiring in a Cross Causes Extensive Genetic Heterogeneity.
IRA2 mutation reveals the phenotypic effects of the cryptic variants by disrupting the transcriptional silencing of one or more genes that contribute to the trait.We also show that this ability to disrupt FLO11 repression is not unique to IRA2
Title: Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions.
Interactions by the fungal Flo11 adhesin depend on a fibronectin type III-like adhesin domain girdled by aromatic bands.
Title: Interactions by the Fungal Flo11 Adhesin Depend on a Fibronectin Type III-like Adhesin Domain Girdled by Aromatic Bands.
Gcn5 plays an important role in the regulatory network of FLO11 expression via Gcn4 by downregulating ICR1 expression, which derepresses FLO11 for promoting pseudohyphal development
Title: The Histone Acetyltransferase Gcn5 Regulates ncRNA-ICR1 and FLO11 Expression during Pseudohyphal Development in Saccharomyces cerevisiae.
Flo11 downregulation causes filamentous and invasive growth of rho mutants.
Title: Dysfunctional mitochondria modulate cAMP-PKA signaling and filamentous and invasive growth of Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion involved in single-species biofilm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in filamentous growth	IDA Inferred from Direct Assay more info	PubMed
involved_in flocculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in invasive growth in response to glucose limitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pseudohyphal growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in single-species surface biofilm formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in fungal-type vacuole	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Flo11p

NP_012284.3

GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal and invasive growth, flocculation, and biofilm formation; major determinant of colony morphology; QTL that controls chronological life span; carries intragenic tandem repeats that are expanded in different strains; required for formation of fibrous interconnections between cells; role in co-flocculation with other yeast species; cleaved and shed from cells, contributing to their surface properties

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

389572..393675 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179541.3 → NP_012284.3 TPA: Flo11p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012284.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVV0, P08068, P08640

UniProtKB/TrEMBL

A0A8H4BZA4, Q6LCS8

Conserved Domains (2) summary

pfam05109
Location:1071 → 1322

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam10182
Location:43 → 193

Flo11; Flo11 domain