ERB1 Erb1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ERB1
Official Full Name: Erb1p
Primary source: SGD:S000004652
Locus tag: YMR049C
See related: AllianceGenome:SGD:S000004652; FungiDB:YMR049C; VEuPathDB:YMR049C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables large ribosomal subunit rRNA binding activity. Involved in rRNA processing and ribosomal large subunit biogenesis. Located in nucleolus. Part of PeBoW complex and preribosome, large subunit precursor. Orthologous to human BOP1 (BOP1 ribosomal biogenesis factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ERB1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (368094..370517, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The erb1Delta161-200 and erb1Delta201-245 deletion mutations block a later step than depletion of Erb1, namely cleavage of the C2 site that initiates removal of the ITS2 spacer. Two other remodeling events fail to occur in these erb1 mutants.
Title: The assembly factor Erb1 functions in multiple remodeling events during 60S ribosomal subunit assembly in S. cerevisiae.
The carboxy-terminal domain of Erb1 is a seven-bladed ss-propeller that binds RNA.
Title: The carboxy-terminal domain of Erb1 is a seven-bladed ß-propeller that binds RNA.
Ytm1, Erb1, and Nop7 are required for assembly of the Nop7-subcomplex in yeast preribosomes
Title: Interactions among Ytm1, Erb1, and Nop7 required for assembly of the Nop7-subcomplex in yeast preribosomes.
Nop7 and Erb1 assemble into preribosomes prior to Ytm1
Title: Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables ribonucleoprotein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoprotein complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA Inferred from Electronic Annotation more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit biogenesis	IPI Inferred from Physical Interaction more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PeBoW complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PeBoW complex	IDA Inferred from Direct Assay more info	PubMed
part_of PeBoW complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleolus	HDA more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	HDA more info	PubMed
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info
part_of preribosome, large subunit precursor	IDA Inferred from Direct Assay more info	PubMed
part_of preribosome, large subunit precursor	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Erb1p

NP_013764.1

Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; binds RNA via its C-terminal domain; homologous to mammalian Bop1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

368094..370517 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182546.1 → NP_013764.1 TPA: Erb1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013764.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZM4, Q04660

UniProtKB/TrEMBL

B3LLU5, B5VPH8, C8ZEQ4

Conserved Domains (3) summary

sd00039
Location:598 → 637

7WD40; WD40 repeat [structural motif]

pfam08145
Location:165 → 426

BOP1NT; BOP1NT (NUC169) domain

cl29593
Location:429 → 805

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...