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SAS2 histone acetyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855157, updated on 18-Sep-2024

Summary

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Official Symbol
SAS2
Official Full Name
histone acetyltransferase
Primary source
SGD:S000004734
Locus tag
YMR127C
See related
AllianceGenome:SGD:S000004734; FungiDB:YMR127C; VEuPathDB:YMR127C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KAT8
Summary
Enables histone acetyltransferase activity. Involved in chromatin organization and histone H3 acetylation. Located in chromatin. Part of SAS acetyltransferase complex. Orthologous to human KAT5 (lysine acetyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SAS2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (522329..523345, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Sto1p Neighboring gene Dlt1p Neighboring gene ATP-dependent RNA helicase ECM16 Neighboring gene Pom152p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Donor Preference Meets Heterochromatin: Moonlighting Activities of a Recombinational Enhancer in Saccharomyces cerevisiae. Dodson AE, et al. Genetics, 2016 Nov. PMID 27655944, Free PMC Article
  2. RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae. Donze D, et al. EMBO J, 2001 Feb 1. PMID 11157758, Free PMC Article
  3. Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors. Secci D, et al. Bioorg Med Chem, 2014 Mar 1. PMID 24513187
  4. Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure. Jo WJ, et al. Toxicol Appl Pharmacol, 2009 Dec 15. PMID 19732783, Free PMC Article
  5. Induction by adozelesin and hydroxyurea of origin recognition complex-dependent DNA damage and DNA replication checkpoints in Saccharomyces cerevisiae. Weinberger M, et al. J Biol Chem, 1999 Dec 10. PMID 10585487

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nut1/Hos1 and Sas2/Rpd3 control the H3 acetylation of two different sets of osmotic stress-induced genes.
    Title: Nut1/Hos1 and Sas2/Rpd3 control the H3 acetylation of two different sets of osmotic stress-induced genes.
  2. Here, we find that Sas2-dependent acetylated histone H4 K16Ac in bulk histones requires passage of the cells through the S-phase of the cell cycle, and the rate of increase in H4 K16Ac depends on both CAF-I and Asf1.
    Title: A link between Sas2-mediated H4 K16 acetylation, chromatin assembly in S-phase by CAF-I and Asf1, and nucleosome assembly by Spt6 during transcription.
  3. Sas2 acetylates histone H4 lysine 16 (H4K16), and telomere shortening in tlc1 mutants was accompanied by a selective and Sas2-dependent increase in subtelomeric H4K16 acetylation.
    Title: Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction.
  4. The functional relationships between Sas2p and the origin recognition complex in DNA replication and transcriptional silencing was examined in different genetic backgrounds.
    Title: Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast.
  5. SAS2 is essential for the organization of the chromatin structure at HMLalpha locus.
    Title: Chromatin assembly factor Asf1p-dependent occupancy of the SAS histone acetyltransferase complex at the silent mating-type locus HMLalpha.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4K16 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide-lysine-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in silent mating-type cassette heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAS acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAS acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone acetyltransferase
NP_013846.1
  • Histone acetyltransferase (HAT) catalytic subunit of the SAS complex; acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family; other members are Sas4p and Sas5p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    522329..523345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182628.1 → NP_013846.1  TPA: histone acetyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013846.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZV0, P40963
    UniProtKB/TrEMBL
    B3LM18, C7GU91, C8ZEY2, G2WKH8, N1NXD5
    Conserved Domains (1) summary
    COG5027
    Location:31 → 338
    SAS2; Histone acetyltransferase (MYST family) [Chromatin structure and dynamics]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40963.1

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