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TPP1 polynucleotide 3'-phosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855188, updated on 18-Sep-2024

Summary

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Official Symbol
TPP1
Official Full Name
polynucleotide 3'-phosphatase
Primary source
SGD:S000004765
Locus tag
YMR156C
See related
AllianceGenome:SGD:S000004765; FungiDB:YMR156C; VEuPathDB:YMR156C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables double-stranded DNA binding activity and polynucleotide 3'-phosphatase activity. Involved in double-strand break repair. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B2 and microcephaly, seizures, and developmental delay. Orthologous to human PNKP (polynucleotide kinase 3'-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TPP1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (570300..571016, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Rim13p Neighboring gene uncharacterized protein Neighboring gene Aim36p Neighboring gene mitochondrial 37S ribosomal protein MRPS8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of DNA 3'-phosphatase active site residues and their differential role in DNA binding, Mg2+ coordination, and catalysis. Deshpande RA, et al. Biochemistry, 2004 Jul 6. PMID 15222769
  2. Uncoupling of 3'-phosphatase and 5'-kinase functions in budding yeast. Characterization of Saccharomyces cerevisiae DNA 3'-phosphatase (TPP1). Vance JR, et al. J Biol Chem, 2001 May 4. PMID 11278831
  3. Yeast Tdp1 regulates the fidelity of nonhomologous end joining. Bahmed K, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160111, Free PMC Article
  4. Error-free and mutagenic processing of topoisomerase 1-provoked damage at genomic ribonucleotides. Sparks JL, et al. EMBO J, 2015 May 5. PMID 25777529, Free PMC Article
  5. Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatases. Vance JR, et al. Mol Cell Biol, 2001 Nov. PMID 11585902, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables polynucleotide 3'-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polynucleotide 3'-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables polynucleotide 3'-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polynucleotide 3'-phosphatase
NP_013877.1
  • DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3'-phosphatase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    570300..571016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182659.1 → NP_013877.1  TPA: polynucleotide 3'-phosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013877.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZX7, Q03796
    UniProtKB/TrEMBL
    A6ZML4, B3LM43, B5VPS8, C7GQ95, C8ZF14, G2WKK7, N1NYH0
    Conserved Domains (1) summary
    cl21460
    Location:30 → 236
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03796.1

Gene LinkOut

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