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HAS1 ATP-dependent RNA helicase HAS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855335, updated on 18-Sep-2024

Summary

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Official Symbol
HAS1
Official Full Name
ATP-dependent RNA helicase HAS1
Primary source
SGD:S000004903
Locus tag
YMR290C
See related
AllianceGenome:SGD:S000004903; FungiDB:YMR290C; VEuPathDB:YMR290C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA binding activity and RNA helicase activity. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and snoRNA release from pre-rRNA. Located in nuclear envelope and nucleolus. Part of preribosome, large subunit precursor. Orthologous to human DDX18 (DEAD-box helicase 18). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HAS1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (850074..851591, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene U2 snRNP complex subunit HSH155 Neighboring gene aminodeoxychorismate lyase ABZ2 Neighboring gene protein kinase TDA1 Neighboring gene Got1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the ATPase and unwinding activities of the yeast DEAD-box protein Has1p and the analysis of the roles of the conserved motifs. Rocak S, et al. Nucleic Acids Res, 2005. PMID 15718299, Free PMC Article
  2. Has1p, a member of the DEAD-box family, is required for 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae. Emery B, et al. Mol Microbiol, 2004 Apr. PMID 15049817
  3. The dynamic three-dimensional organization of the diploid yeast genome. Kim S, et al. Elife, 2017 May 24. PMID 28537556, Free PMC Article
  4. Studies of the expression of human poly(ADP-ribose) polymerase-1 in Saccharomyces cerevisiae and identification of PARP-1 substrates by yeast proteome microarray screening. Tao Z, et al. Biochemistry, 2009 Dec 15. PMID 19877712
  5. Function of the C-terminal domain of the DEAD-box protein Mss116p analyzed in vivo and in vitro. Mohr G, et al. J Mol Biol, 2008 Feb 1. PMID 18096186, Free PMC Article

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. roles in triggering release of the U14 snoRNP, a critical event during early 40S maturation, and in driving assembly of domain I of pre-60S complexes
    Title: RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes.
  2. The data supports a model in which Has1 helps to establish domain I architecture of 5.8S/25S rRNA to prevent pre-rRNA turnover and couples domain I folding with consecutive pre-rRNA processing steps.
    Title: Has1 regulates consecutive maturation and processing steps for assembly of 60S ribosomal subunits.
  3. Mutational analysis of the conserved residues in motifs that are important for ATPase and unwinding activities of Has1p.
    Title: Characterization of the ATPase and unwinding activities of the yeast DEAD-box protein Has1p and the analysis of the roles of the conserved motifs.
  4. Has1p helicase is required for snoRNA release from pre-rRNA and production of the U6 snRNP
    Title: The helicase Has1p is required for snoRNA release from pre-rRNA.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on RNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in snoRNA release from pre-rRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor HDA PubMed 
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ATP-dependent RNA helicase HAS1
NP_014017.1
  • ATP-dependent RNA helicase; involved in the biogenesis of 40S and 60S ribosome subunits; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    850074..851591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182797.1 → NP_014017.1  TPA: ATP-dependent RNA helicase HAS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014017.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0B7, Q03532
    UniProtKB/TrEMBL
    A6ZN06, B3LMH8, B5VQ58, C7GTK9, C8ZFF7, G2WKZ9, N1NYU8
    Conserved Domains (2) summary
    COG0513
    Location:16 → 475
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd17942
    Location:53 → 251
    DEADc_DDX18; DEAD-box helicase domain of DEAD box protein 18
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03532.1

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