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BXI1 Bxi1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855411, updated on 7-Jul-2024

Summary

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Gene symbol
BXI1
Gene description
Bxi1p
Primary source
FungiDB:YNL305C
Locus tag
YNL305C
See related
SGD:S000005249; AllianceGenome:SGD:S000005249; VEuPathDB:YNL305C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YBH3
Summary
Involved in apoptotic process; calcium-mediated signaling; and endoplasmic reticulum unfolded protein response. Located in endoplasmic reticulum; fungal-type vacuole; and mitochondrion. Orthologous to several human genes including TMBIM4 (transmembrane BAX inhibitor motif containing 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BXI1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (58898..59791, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene serine/threonine/tyrosine protein kinase MCK1 Neighboring gene mitochondrial 37S ribosomal protein YmS18 Neighboring gene Rab family GTPase YPT11 Neighboring gene ribosomal 40S subunit protein S19B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast Bax inhibitor, Bxi1p, is an ER-localized protein that links the unfolded protein response and programmed cell death in Saccharomyces cerevisiae. Cebulski J, et al. PLoS One, 2011. PMID 21673967, Free PMC Article
  2. Evolutionarily conserved cytoprotection provided by Bax Inhibitor-1 homologs from animals, plants, and yeast. Chae HJ, et al. Gene, 2003 Dec 24. PMID 14659883
  3. Heterologous expression of anti-apoptotic human 14-3-3β/α enhances iron-mediated programmed cell death in yeast. Eid R, et al. PLoS One, 2017. PMID 28854230, Free PMC Article
  4. Role of CNC1 gene in TDP-43 aggregation-induced oxidative stress-mediated cell death in S. cerevisiae model of ALS. Bharathi V, et al. Biochim Biophys Acta Mol Cell Res, 2021 May. PMID 33647321
  5. The cell death protease Kex1p is essential for hypochlorite-induced apoptosis in yeast. Carmona-Gutierrez D, et al. Cell Cycle, 2013 Jun 1. PMID 23656787, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast Bxi1/Ybh3 mediates conserved mitophagy and apoptosis in yeast and mammalian cells: convergence in Bcl-2 family.
    Title: Yeast Bxi1/Ybh3 mediates conserved mitophagy and apoptosis in yeast and mammalian cells: convergence in Bcl-2 family.
  2. Yeast Bax Inhibitor (Bxi1p/Ybh3p) Is Not Required for the Action of Bcl-2 Family Proteins on Cell Viability.
    Title: Yeast Bax Inhibitor (Bxi1p/Ybh3p) Is Not Required for the Action of Bcl-2 Family Proteins on Cell Viability.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bxi1p
NP_014094.1
  • Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    58898..59791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183143.1 → NP_014094.1  TPA: Bxi1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014094.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0P0, P48558, Q6B2Q1
    UniProtKB/TrEMBL
    A0A8H4BWS5, A6ZSH5, B3LPD9, B5VQB5, C7GWQ2, C8ZGL9, G2WLG4, N1NWN4
    Conserved Domains (1) summary
    cd10429
    Location:21 → 294
    GAAP_like; Golgi antiapoptotic protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48558.1

Gene LinkOut

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