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ERG24 delta(14)-sterol reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855441, updated on 4-Aug-2024

Summary

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Gene symbol
ERG24
Gene description
delta(14)-sterol reductase
Primary source
FungiDB:YNL280C
Locus tag
YNL280C
See related
SGD:S000005224; AllianceGenome:SGD:S000005224; VEuPathDB:YNL280C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables delta14-sterol reductase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor) and TM7SF2 (transmembrane 7 superfamily member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ERG24 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (109095..110411, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pop3p Neighboring gene Hch1p Neighboring gene pheromone-regulated protein PRM1 Neighboring gene Caf120p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inhibition of ergosterol synthesis by novel antifungal compounds targeting C-14 reductase. Hata M, et al. Med Mycol, 2010 Jun. PMID 20392153
  2. Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site. Jia N, et al. Antimicrob Agents Chemother, 2002 Apr. PMID 11897574, Free PMC Article
  3. Radio-detection high-performance liquid chromatographic enzyme assay for inhibitors of fungal sterol delta 14-reductase. Steel CC. J Chromatogr, 1991 May 31. PMID 1939455
  4. Cloning, sequencing, and disruption of the gene encoding sterol C-14 reductase in Saccharomyces cerevisiae. Lorenz RT, et al. DNA Cell Biol, 1992 Nov. PMID 1418625
  5. Construction and growth properties of a yeast strain defective in sterol 14-reductase. Marcireau C, et al. Curr Genet, 1992 Oct. PMID 1394506

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables delta14-sterol reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delta14-sterol reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables delta14-sterol reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables delta14-sterol reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
delta(14)-sterol reductase
NP_014119.1
  • C-14 sterol reductase; acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    109095..110411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183118.1 → NP_014119.1  TPA: delta(14)-sterol reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014119.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0R4, P32462
    UniProtKB/TrEMBL
    A6ZRG5, B3LPB9, B5VQD5, C7GP84, C8ZGP1, G2WLI6, N1NXX5
    Conserved Domains (1) summary
    pfam01222
    Location:8 → 438
    ERG4_ERG24; Ergosterol biosynthesis ERG4/ERG24 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32462.1

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