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PGA1 Pga1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855564, updated on 1-Aug-2024

Summary

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Gene symbol
PGA1
Gene description
Pga1p
Primary source
FungiDB:YNL158W
Locus tag
YNL158W
See related
SGD:S000005102; AllianceGenome:SGD:S000005102; VEuPathDB:YNL158W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mannosyltransferase activity. Involved in GPI anchor biosynthetic process. Is integral component of endoplasmic reticulum membrane. Part of mannosyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PGA1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (339612..340208)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Ygp1p Neighboring gene Asi2p Neighboring gene phosphatase regulator Neighboring gene Nsg2p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pga1 is an essential component of Glycosylphosphatidylinositol-mannosyltransferase II of Saccharomyces cerevisiae. Sato K, et al. Mol Biol Cell, 2007 Sep. PMID 17615295, Free PMC Article
  2. Disruption and basic phenotypic analysis of six novel genes from the left arm of chromosome XIV of Saccharomyces cerevisiae. Dueñas E, et al. Yeast, 1999 Jan 15. PMID 10028186
  3. Long 3'-UTRs target wild-type mRNAs for nonsense-mediated mRNA decay in Saccharomyces cerevisiae. Kebaara BW, et al. Nucleic Acids Res, 2009 May. PMID 19270062, Free PMC Article
  4. Members of the RSC chromatin-remodeling complex are required for maintaining proper nuclear envelope structure and pore complex localization. Titus LC, et al. Mol Biol Cell, 2010 Mar 15. PMID 20110349, Free PMC Article
  5. Assigning function to yeast proteins by integration of technologies. Hazbun TR, et al. Mol Cell, 2003 Dec. PMID 14690591

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pga1 is an additional essential component of the yeast Glycosylphosphatidylinositol-mannosyltransferase II.
    Title: Pga1 is an essential component of Glycosylphosphatidylinositol-mannosyltransferase II of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to mannosyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables mannosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mannosyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mannosyltransferase complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of mannosyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope HDA PubMed 

General protein information

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Preferred Names
Pga1p
NP_014241.1
  • Essential component of GPI-mannosyltransferase II; complex is responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interactions with secretory pathway genes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    339612..340208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182996.1 → NP_014241.1  TPA: Pga1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014241.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W125, P53896
    UniProtKB/TrEMBL
    A6ZRS6, B3LP13, B5VQP7, C7GXV8, C8ZG71, G2WLU9, N1NXT3
    Conserved Domains (1) summary
    pfam10333
    Location:14 → 189
    Pga1; GPI-Mannosyltransferase II co-activator
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53896.1

Gene LinkOut

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