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ESBP6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855598, updated on 11-Sep-2024

Summary

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Official Symbol
ESBP6
Primary source
SGD:S000005069
Locus tag
YNL125C
See related
AllianceGenome:SGD:S000005069; FungiDB:YNL125C; VEuPathDB:YNL125C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MCH3
Summary
Predicted to enable symporter activity. Predicted to be involved in transmembrane transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome; cataract 47; familial hyperinsulinemic hypoglycemia 7; and intellectual disability. Orthologous to several human genes including SLC16A12 (solute carrier family 16 member 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (390146..392167, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Far11p Neighboring gene Spc98p Neighboring gene RNA-binding snoRNP assembly protein Neighboring gene Nma111p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of ESBP6 improves lactic acid resistance and production in Saccharomyces cerevisiae. Sugiyama M, et al. J Biosci Bioeng, 2016 Oct. PMID 27102264
  2. Elucidating aromatic acid tolerance at low pH in Saccharomyces cerevisiae using adaptive laboratory evolution. Pereira R, et al. Proc Natl Acad Sci U S A, 2020 Nov 10. PMID 33106428, Free PMC Article
  3. The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Makuc J, et al. Yeast, 2001 Sep 15. PMID 11536335
  4. Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling. Stefely JA, et al. Nat Biotechnol, 2016 Nov. PMID 27669165, Free PMC Article
  5. A CRISPR/Cas9-based exploration into the elusive mechanism for lactate export in Saccharomyces cerevisiae. Mans R, et al. FEMS Yeast Res, 2017 Dec 1. PMID 29145596

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Esbp6p
NP_014274.1
  • Protein with similarity to monocarboxylate permeases; appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    390146..392167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182963.1 → NP_014274.1  TPA: Esbp6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014274.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W158, P53918
    UniProtKB/TrEMBL
    A6ZRV9, G2WLY2
    Conserved Domains (1) summary
    cd17352
    Location:212 → 606
    MFS_MCT_SLC16; Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53918.1

Gene LinkOut

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