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YPT53 Rab family GTPase YPT53 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855631, updated on 1-Aug-2024

Summary

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Gene symbol
YPT53
Gene description
Rab family GTPase YPT53
Primary source
FungiDB:YNL093W
Locus tag
YNL093W
See related
SGD:S000005037; AllianceGenome:SGD:S000005037; VEuPathDB:YNL093W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity. Involved in Golgi to endosome transport; endocytosis; and protein targeting to vacuole. Located in late endosome. Orthologous to human RAB5A (RAB5A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YPT53 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (449868..450530)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene phosphatidate phosphatase APP1 Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene Nst1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The nutrient stress-induced small GTPase Rab5 contributes to the activation of vesicle trafficking and vacuolar activity. Nakatsukasa K, et al. J Biol Chem, 2014 Jul 25. PMID 24923442, Free PMC Article
  2. Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. Singer-Krüger B, et al. J Cell Biol, 1994 Apr. PMID 8163546, Free PMC Article
  3. Ordering of compartments in the yeast endocytic pathway. Prescianotto-Baschong C, et al. Traffic, 2002 Jan. PMID 11872141
  4. Mapping of Vps21 and HOPS binding sites in Vps8 and effect of binding site mutants on endocytic trafficking. Pawelec A, et al. Eukaryot Cell, 2010 Apr. PMID 20173035, Free PMC Article
  5. Expression, purification, and biochemical properties of Ypt/Rab GTPase-activating proteins of Gyp family. Will E, et al. Methods Enzymol, 2001. PMID 11210571

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. when cells are exposed to nutrient stress for an extended period of time, the up-regulated Ypt53 and the constitutive Vps21 function redundantly to maintain these activities.
    Title: The nutrient stress-induced small GTPase Rab5 contributes to the activation of vesicle trafficking and vacuolar activity.
  2. Data indicate that Cells lacking both Vps9 and Muk1 closely phenocopy double and triple knock-out strains lacking Rab5 paralogs.
    Title: Vps9 family protein Muk1 is the second Rab5 guanosine nucleotide exchange factor in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to endosome transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rab family GTPase YPT53
NP_014306.3
  • Stress-induced Rab family GTPase; required for vacuolar protein sorting and endocytosis; involved in ionic stress tolerance; similar to Vps21p and Ypt52p; functional homolog of Vps21p; mammalian Rab5 homolog; YPT53 has a paralog, VPS21, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    449868..450530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182931.3 → NP_014306.3  TPA: Rab family GTPase YPT53 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014306.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W187, P36019, Q45TZ5
    UniProtKB/TrEMBL
    A6ZRY8, B3LNV1, B5VQV0, C8ZGD8, G2WM12, N1NWK8
    Conserved Domains (1) summary
    cd01860
    Location:12 → 180
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36019.1

Gene LinkOut

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