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END3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855640, updated on 11-Sep-2024

Summary

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Official Symbol
END3
Primary source
SGD:S000005028
Locus tag
YNL084C
See related
AllianceGenome:SGD:S000005028; FungiDB:YNL084C; VEuPathDB:YNL084C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein-macromolecule adaptor activity. Involved in ascospore wall assembly and endocytosis. Located in cell periphery and mating projection tip. Part of actin cytoskeleton-regulatory complex. Orthologous to human EPS15 (epidermal growth factor receptor pathway substrate 15). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (470053..471102, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Snn1p Neighboring gene Mkt1p Neighboring gene Ca(2+)-binding ATP:ADP antiporter SAL1 Neighboring gene ATP-binding mismatch repair protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of Colchicine on actin polymerization dynamics: as a potent anti-angiogenic factor. Pathak S, et al. J Biomol Struct Dyn, 2022. PMID 34424806
  2. In vitro, in vivo and in silico rationale for the muscle loss due to therapeutic drugs used in the treatment of Mycobacterium tuberculosis infection. Pathak S, et al. J Biomol Struct Dyn, 2022 Jan. PMID 32795137
  3. Resveratrol-Loaded Lipid Nanocarriers Are Internalized By Endocytosis in Yeast. Barbosa C, et al. J Nat Prod, 2019 May 24. PMID 30964667
  4. A novel toxicity mechanism of CdSe nanoparticles to Saccharomyces cerevisiae: enhancement of vacuolar membrane permeabilization (VMP). Sun M, et al. Chem Biol Interact, 2014 Sep 5. PMID 25014418
  5. End3p-mediated endocytosis is required for spore wall formation in Saccharomyces cerevisiae. Morishita M, et al. Genetics, 2005 Aug. PMID 15944351, Free PMC Article

See all (140) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The C-terminal End3 Repeats of End3 associate with the N-terminal part of Pan1's central coiled-coil region.
    Title: Targeted disruption of an EH-domain protein endocytic complex, Pan1-End3.
  2. END3-mediated endocytosis is required for spore wall formation.
    Title: End3p-mediated endocytosis is required for spore wall formation in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
  
involved_in ascospore wall assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within reticulophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
part_of actin cytoskeleton-regulatory complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of actin cytoskeleton-regulatory complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cell periphery HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mating projection tip HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
End3p
NP_014315.1
  • EH domain-containing protein involved in endocytosis; actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    470053..471102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182922.1 → NP_014315.1  TPA: End3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014315.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W195, P39013, Q8TFC4, Q8TFD0, Q8TG51
    UniProtKB/TrEMBL
    C7GUN4, N1NXI0
    Conserved Domains (3) summary
    smart00027
    Location:123 → 221
    EH; Eps15 homology domain
    pfam12763
    Location:1 → 104
    EF-hand_4; Cytoskeletal-regulatory complex EF hand
    pfam12761
    Location:186 → 345
    End3; Actin cytoskeleton-regulatory complex protein END3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39013.1

Gene LinkOut

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