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PDR18 ATP-binding cassette multidrug transporter PDR18 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855807, updated on 1-Aug-2024

Summary

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Gene symbol
PDR18
Gene description
ATP-binding cassette multidrug transporter PDR18
Primary source
FungiDB:YNR070W
Locus tag
YNR070W
See related
SGD:S000005353; AllianceGenome:SGD:S000005353; VEuPathDB:YNR070W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable ABC-type transporter activity and ATP binding activity. Involved in response to xenobiotic stimulus and sterol homeostasis. Located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to several human genes including ABCA10 (ATP binding cassette subfamily A member 10); ABCA3 (ATP binding cassette subfamily A member 3); and ABCA5 (ATP binding cassette subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PDR18 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (765375..769376)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bsc5p Neighboring gene aldose 1-epimerase superfamily protein Neighboring gene hexose transporter HXT17

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ABC transporter Pdr18 is required for yeast thermotolerance due to its role in ergosterol transport and plasma membrane properties. Godinho CP, et al. Environ Microbiol, 2021 Jan. PMID 32985771, Free PMC Article
  2. Increased expression of the yeast multidrug resistance ABC transporter Pdr18 leads to increased ethanol tolerance and ethanol production in high gravity alcoholic fermentation. Teixeira MC, et al. Microb Cell Fact, 2012 Jul 27. PMID 22839110, Free PMC Article
  3. The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance. Cabrito TR, et al. Biochem J, 2011 Dec 1. PMID 21831043, Free PMC Article
  4. Combined phylogeny and neighborhood analysis of the evolution of the ABC transporters conferring multiple drug resistance in hemiascomycete yeasts. Seret ML, et al. BMC Genomics, 2009 Oct 1. PMID 19796374, Free PMC Article
  5. The Paralogous Genes PDR18 and SNQ2, Encoding Multidrug Resistance ABC Transporters, Derive From a Recent Duplication Event, PDR18 Being Specific to the Saccharomyces Genus. Godinho CP, et al. Front Genet, 2018. PMID 30374366, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ABC transporter Pdr18 is required for yeast thermotolerance due to its role in ergosterol transport and plasma membrane properties.
    Title: The ABC transporter Pdr18 is required for yeast thermotolerance due to its role in ergosterol transport and plasma membrane properties.
  2. results of the present study suggest that Pdr18 plays a role in plasma membrane sterol incorporation, this physiological trait contributing to an MDR phenotype.
    Title: The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ABC-type xenobiotic transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sterol homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ATP-binding cassette multidrug transporter PDR18
NP_014468.3
  • Transporter of the ATP-binding cassette (ABC) family; role in plasma membrane sterol incorporation; implicated in pleiotropic drug resistance; provides resistance to ethanol stress and contributes to a decreased intracellular accumulation of ethanol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    765375..769376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183247.4 → NP_014468.3  TPA: ATP-binding cassette multidrug transporter PDR18 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014468.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1P5, P53756
    UniProtKB/TrEMBL
    A6ZSE4, B5VR95
    Conserved Domains (1) summary
    TIGR00956
    Location:1 → 1333
    3a01205; Pleiotropic Drug Resistance (PDR) Family protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53756.1

Gene LinkOut

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