SUI3 translation initiation factor eIF2 subunit beta [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: SUI3
Gene description: translation initiation factor eIF2 subunit beta
Primary source: FungiDB:YPL237W
Locus tag: YPL237W
See related: SGD:S000006158; AllianceGenome:SGD:S000006158; VEuPathDB:YPL237W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables mRNA binding activity; translation initiation factor activity; and translation initiation factor binding activity. Contributes to GTP binding activity and methionyl-initiator methionine tRNA binding activity. Involved in formation of translation preinitiation complex. Part of eukaryotic 43S preinitiation complex; eukaryotic translation initiation factor 2 complex; and multi-eIF complex. Used to study leukodystrophy. Orthologous to human EIF2S2 (eukaryotic translation initiation factor 2 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SUI3 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (100496..101353)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

eIF2beta or eIF1 substitutions disrupting these contacts increase initiation at UUG codons, and compound substitutions also derepress translation of GCN4, indicating slower TC recruitment.
Title: A network of eIF2β interactions with eIF1 and Met-tRNAi promotes accurate start codon selection by the translation preinitiation complex.
These data uncover competition between eIF2B and eIF5 for eIF2-GTP/Met-tRNAi ternary complexes and identify that phosphorylated eIF2-GTP translation initiation intermediate complexes can be inhibited by eIF2B.
Title: Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes.
Data indicate that Cdc123 is a specific assembly factor for eukaryotic translation initiation factor 2 (eIF) subunit alpha (sui2), subunit beta (sui3) and subunit gamma (GCD11), which is indispensable for the onset of protein synthesis.
Title: Translation initiation requires cell division cycle 123 (Cdc123) to facilitate biogenesis of the eukaryotic initiation factor 2 (eIF2).
eIF1 autoregulates translation in yeast and discrimination against poor sequence context in vivo depends on specific domains and residues in eIF1, eIF1A, and eIF2beta
Title: Functional elements in initiation factors 1, 1A, and 2β discriminate against poor AUG context and non-AUG start codons.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to methionyl-initiator methionine tRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables translation initiation factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor binding	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in formation of translation preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in formation of translation preinitiation complex	IDA Inferred from Direct Assay more info	PubMed
involved_in formation of translation preinitiation complex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 43S preinitiation complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 2 complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of multi-eIF complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: translation initiation factor eIF2 subunit beta

NP_015087.1

Beta subunit of the translation initiation factor eIF2; involved in the identification of the start codon; proposed to be involved in mRNA binding

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

100496..101353

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184051.1 → NP_015087.1 TPA: translation initiation factor eIF2 subunit beta [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015087.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3D3, P09064, Q6B200

UniProtKB/TrEMBL

A6ZW18, B3LKJ4, C7GU76, C8ZIE2, N1NVL4

Conserved Domains (1) summary

COG1601
Location:124 → 281

GCD7; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]