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NSL1 MIND complex subunit NSL1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855843, updated on 18-Sep-2024

Summary

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Official Symbol
NSL1
Official Full Name
MIND complex subunit NSL1
Primary source
SGD:S000006154
Locus tag
YPL233W
See related
AllianceGenome:SGD:S000006154; FungiDB:YPL233W; VEuPathDB:YPL233W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in chromosome segregation. Located in kinetochore and spindle pole. Part of nuclear MIS12/MIND complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NSL1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (106172..106822)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene RuvB family ATP-dependent DNA helicase reptin Neighboring gene H(+)-transporting V0 sector ATPase subunit c' Neighboring gene syntaxin Neighboring gene trifunctional fatty acid synthase subunit FAS2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C-Terminal Motifs of the MTW1 Complex Cooperatively Stabilize Outer Kinetochore Assembly in Budding Yeast. Ghodgaonkar-Steger M, et al. Cell Rep, 2020 Sep 29. PMID 32997987
  2. Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Dimitrova YN, et al. Cell, 2016 Nov 3. PMID 27881300, Free PMC Article
  3. Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex. Scharfenberger M, et al. EMBO J, 2003 Dec 15. PMID 14657030, Free PMC Article
  4. Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae. Euskirchen GM. Eukaryot Cell, 2002 Apr. PMID 12455957, Free PMC Article
  5. An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Pinsky BA, et al. Dev Cell, 2003 Nov. PMID 14602074

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic sister chromatid segregation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of MIS12/MIND type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MIS12/MIND type complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MIND complex subunit NSL1
NP_015091.1
  • Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    106172..106822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184047.1 → NP_015091.1  TPA: MIND complex subunit NSL1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015091.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3D7, Q12143, Q6B152
    UniProtKB/TrEMBL
    A6ZW22, B3LKJ8, C7GU72, C8ZIE6, G2WNV2, N1NVM3
    Conserved Domains (1) summary
    pfam08641
    Location:62 → 194
    Mis14; Kinetochore protein Mis14 like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12143.1

Gene LinkOut

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