ACM1 Acm1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ACM1
Gene description: Acm1p
Primary source: FungiDB:YPL267W
Locus tag: YPL267W
See related: SGD:S000006188; AllianceGenome:SGD:S000006188; VEuPathDB:YPL267W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ubiquitin-protein transferase inhibitor activity. Involved in negative regulation of ubiquitin protein ligase activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ACM1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (38169..38798)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The anaphase-promoting complex/cyclosome (APC/C) is suppressed by the small pseudosubstrate inhibitor Acm1. Acm1 D-box extension inhibits reaction processivity by perturbing the normal interaction with Doc1/Apc10. These results reveal a simple, elegant mode of pseudosubstrate inhibition that combines high-affinity activator binding with specific disruption of Doc1/Apc10 function in processive ubiquitylation.
Title: The pseudosubstrate inhibitor Acm1 inhibits the anaphase-promoting complex/cyclosome by combining high-affinity activator binding with disruption of Doc1/Apc10 function.
the structure of an Acm1-Cdh1 complex
Title: Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex.
Cells lacking Acm1 have defects in nuclear positioning and spindle morphology during mitosis.
Title: Acm1 contributes to nuclear positioning by inhibiting Cdh1-substrate interactions.
unique property of the Acm1 degron sequences results from an unusually high affinity interaction with the substrate receptor site on the WD40 domain of Cdh1 that may serve both to promote APC inhibition and protect Acm1 from destruction.
Title: Unique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complex.
Cdc28 serves dual roles in inhibiting Cdh1-dependent anaphase-promoting complex (APC) activity during the cell cycle: stabilization of the Cdh1 inhibitor Acm1 and direct phosphorylation of Cdh1 to prevent its association with the APC.
Title: Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation.
Data show that in budding yeast the activation of APC(Cdh1) is controlled in part by destruction of the Cdh1 inhibitor Acm1.
Title: Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.
the opposing actions of Cdc28 and Cdc14 are primary factors limiting Acm1 to the interval from G(1)/S to late mitosis and are capable of establishing APC-independent expression patterns similar to APC substrates
Title: Cdc28 and Cdc14 control stability of the anaphase-promoting complex inhibitor Acm1.
Acm1 and Bmh1/Bmh2 constitute a specialized inhibitor of anaphase-promoting complex/CCdh1.
Title: Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ubiquitin-protein transferase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase inhibitor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ubiquitin-protein transferase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Acm1p

NP_015056.1

Pseudosubstrate inhibitor of the APC/C; suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein; the anaphase-promoting complex/cyclosome is also known as APC/C