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TYW1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855894, updated on 11-Sep-2024

Summary

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Official Symbol
TYW1
Primary source
SGD:S000006128
Locus tag
YPL207W
See related
AllianceGenome:SGD:S000006128; FungiDB:YPL207W; VEuPathDB:YPL207W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables S-adenosyl-L-methionine binding activity. Involved in wybutosine biosynthetic process. Located in endoplasmic reticulum. Orthologous to several human genes including TYW1 (tRNA-yW synthesizing protein 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (159909..162341)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene aurora kinase Neighboring gene protein-lysine N-methyltransferase Neighboring gene phosphatidylglycerol phospholipase Neighboring gene serine/threonine protein kinase HRR25

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Eukaryotic TYW1 Is a Radical SAM Flavoenzyme. Young AP, et al. Biochemistry, 2021 Jul 13. PMID 34184886, Free PMC Article
  2. Yap5 protein-regulated transcription of the TYW1 gene protects yeast from high iron toxicity. Li L, et al. J Biol Chem, 2011 Nov 4. PMID 21917924, Free PMC Article
  3. Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs. Waas WF, et al. J Biol Chem, 2005 Nov 11. PMID 16162496
  4. Production of 1,2,4-butanetriol from xylose by Saccharomyces cerevisiae through Fe metabolic engineering. Bamba T, et al. Metab Eng, 2019 Dec. PMID 31434008
  5. Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. Noma A, et al. EMBO J, 2006 May 17. PMID 16642040, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables S-adenosyl-L-methionine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-4-demethylwyosine synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in wybutosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wybutosine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in wybutosine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative tRNA 4-demethylwyosine synthase
NP_015117.1
  • Iron-sulfur protein required for synthesis of wybutosine modified tRNA; wybutosine is a modified guanosine found at 3'-position adjacent to anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    159909..162341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184021.1 → NP_015117.1  TPA: putative tRNA 4-demethylwyosine synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015117.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3G3, Q08960
    UniProtKB/TrEMBL
    A6ZW48, B3LKM3, C8ZIH2
    Conserved Domains (2) summary
    COG0731
    Location:445 → 762
    Tyw1; Wyosine [tRNA(Phe)-imidazoG37] synthetase, radical SAM superfamily [Translation, ribosomal structure and biogenesis]
    pfam00258
    Location:207 → 354
    Flavodoxin_1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08960.1

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