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DBP1 putative DEAD-box ATP-dependent RNA helicase DBP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855984, updated on 29-Jun-2024

Summary

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Gene symbol
DBP1
Gene description
putative DEAD-box ATP-dependent RNA helicase DBP1
Primary source
FungiDB:YPL119C
Locus tag
YPL119C
See related
SGD:S000006040; AllianceGenome:SGD:S000006040; VEuPathDB:YPL119C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LPH8
Summary
Enables ATP hydrolysis activity; DNA/RNA helicase activity; and single-stranded RNA binding activity. Involved in positive regulation of formation of translation preinitiation complex and translational initiation. Located in cytoplasm. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to several human genes including DDX3X (DEAD-box helicase 3 X-linked) and DDX3Y (DEAD-box helicase 3 Y-linked). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DBP1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (324411..326264, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene beclin 1 Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein MRP51 Neighboring gene isopentenyl-diphosphate delta-isomerase IDI1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional interplay between DEAD-box RNA helicases Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in vivo. Sen ND, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31299079, Free PMC Article
  2. The molecular evolution of PL10 homologs. Chang TC, et al. BMC Evol Biol, 2010 May 3. PMID 20438638, Free PMC Article
  3. Dynamics and processivity of 40S ribosome scanning on mRNA in yeast. Berthelot K, et al. Mol Microbiol, 2004 Feb. PMID 14763975
  4. A suppressor of yeast spp81/ded1 mutations encodes a very similar putative ATP-dependent RNA helicase. Jamieson DJ, et al. Mol Microbiol, 1991 Apr. PMID 1857205
  5. A mutation in the C31 subunit of Saccharomyces cerevisiae RNA polymerase III affects transcription initiation. Thuillier V, et al. EMBO J, 1995 Jan 16. PMID 7835345, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional interplay between Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in Saccharomyces cerevisiae has been reported.
    Title: Functional interplay between DEAD-box RNA helicases Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in vivo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA/RNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of formation of translation preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative DEAD-box ATP-dependent RNA helicase DBP1
NP_015206.1
  • ATP-dependent RNA helicase of the DEAD-box protein family; accelerates eIF4F-dependent assembly of 48S translation preinitiation complex (PIC), stimulating recruitment of mRNAs with long, structured 5'-UTRs; cooperates with DEAD-box RNA helicase and paralog Ded1p, stimulating PIC attachment and highly processive scanning by the 40S ribosomal subunit; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    324411..326264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183933.1 → NP_015206.1  TPA: putative DEAD-box ATP-dependent RNA helicase DBP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015206.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3P9, P20446, P24784
    UniProtKB/TrEMBL
    A0A8H4BUQ8, B3LKV6, C7GJ72, C8ZIR1, N1NVG6
    Conserved Domains (1) summary
    COG0513
    Location:129 → 595
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24784.2

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