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GPI2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856029, updated on 11-Sep-2024

Summary

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Official Symbol
GPI2
Primary source
SGD:S000005997
Locus tag
YPL076W
See related
AllianceGenome:SGD:S000005997; FungiDB:YPL076W; VEuPathDB:YPL076W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GCR4
Summary
Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum. Part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human PIGC (phosphatidylinositol glycan anchor biosynthesis class C). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (410443..411285)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene F1F0 ATP synthase subunit 4 Neighboring gene uncharacterized protein Neighboring gene transcription regulator GCR1 Neighboring gene putative AAA family ATPase YTA6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae Gpi2, an accessory subunit of the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis, selectively complements some of the functions of its homolog in Candida albicans. Yadav A, et al. Glycoconj J, 2014 Oct. PMID 25117514
  2. Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes. Schneiter R, et al. Biochem J, 2004 Aug 1. PMID 15270698, Free PMC Article
  3. A new essential gene GCR4 located in the upstream region of GCR1. Uemura H, et al. Yeast, 1995 Sep 15. PMID 7502585
  4. Gpi19, the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis. Newman HA, et al. Eukaryot Cell, 2005 Nov. PMID 16278447, Free PMC Article
  5. Gpi1, a Saccharomyces cerevisiae protein that participates in the first step in glycosylphosphatidylinositol anchor synthesis. Leidich SD, et al. J Biol Chem, 1996 Nov 1. PMID 8910381

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol N-acetylglucosaminyltransferase activity IC
Inferred by Curator
more info
  
enables phosphatidylinositol N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase
NP_015249.1
  • Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    410443..411285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183890.1 → NP_015249.1  TPA: phosphatidylinositol N-acetylglucosaminyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015249.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3U0, P46961, P48014
    UniProtKB/TrEMBL
    A6ZWH4, B3LKZ4, B5VT86, C7GTY2, C8ZIV4, G2WPA5, N1NX81
    Conserved Domains (1) summary
    pfam06432
    Location:6 → 273
    GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46961.2

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