RPC40 DNA-directed RNA polymerase core subunit RPC40 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: RPC40
Gene description: DNA-directed RNA polymerase core subunit RPC40
Primary source: FungiDB:YPR110C
Locus tag: YPR110C
See related: SGD:S000006314; AllianceGenome:SGD:S000006314; VEuPathDB:YPR110C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RPC5
Summary: Contributes to RNA polymerase I activity and RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase I; and transposon integration. Part of RNA polymerase I complex and RNA polymerase III complex. Used to study Treacher Collins syndrome. Human ortholog(s) of this gene implicated in Treacher Collins syndrome; Treacher Collins syndrome 3; and hypomyelinating leukodystrophy 11. Orthologous to human POLR1C (RNA polymerase I and III subunit C). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase I activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase I activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase I activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase III activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase III activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase III activity	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in tRNA transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase I complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_015435.1

RNA polymerase subunit AC40; common to RNA polymerase I and III; predominant determinant targeting Ty1 integration upstream of Pol III-transcribed genes

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